porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo12350porozendo-12350Research ArticleНаучный обзорReviewВлияние комплексной терапии медуллобластомы в детском и подростковом возрасте на минеральную плотность костной тканиEffect of complex therapy of medulloblastoma in childhood and adolescence on bone mineral densityhttps://orcid.org/0000-0001-7879-8495КимЕкатерина ИгоревнаKimEkaterina I.

студентка лечебного факультета

medical student

kat-alex2007@mail.ruhttps://orcid.org/0000-0003-2320-1051ГолоунинаОльга ОлеговнаGolouninaOlga O.

студентка 2-го курса лечебного факультета

Student, Medical faculty

olga.golounina@mail.ruhttps://orcid.org/0000-0001-6073-328XПавловаМария ГеннадиевнаPavlovaMaria G.

К.м.н., врач-эндокринолог, кафедра эндокринологии

Ph.D., M.D.endocrinologist, Chair of endocrinology

mgpavlova68@rambler.ruhttps://orcid.org/0000-0002-4704-8453ЮдинаАлла ЕвгеньевнаYudinaAlla E.

Аспирант, врач-эндокринолог, кафедра эндокринологии

Postgraduate student, M.D. Chair of endocrinology

alla1301@yandex.ruhttps://orcid.org/0000-0002-3026-6315ФадеевВалентин ВикторовичFadeevValentin V.

д.м.н., профессор, член-корреспондент РАН

MD, PhD, Professor

walfad@mail.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2019160820202242733Copyright © Ким Е.И., Голоунина О.О., Павлова М.Г., Юдина А.Е., Фадеев В.В., 20192019Ким Е.И., Голоунина О.О., Павлова М.Г., Юдина А.Е., Фадеев В.В.Kim E.I., Golounina O.O., Pavlova M.G., Yudina A.E., Fadeev V.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/12350

Медуллобластома – наиболее распространенная злокачественная опухоль задней черепной ямки детского возраста. Комплексный подход к лечению, включающий операцию, полихимиотерапию и лучевую терапию, существенно увеличивает выживаемость пациентов. Однако это неизбежно приводит к развитию различных отдаленных последствий со стороны эндокринной системы, в том числе оказывает негативное влияние на костную ткань. Снижение скорости линейного роста, низкий конечный рост, недостаточный набор пиковой костной массы – хорошо известные отдаленные последствия лечения. В обзоре на основании данных российских и зарубежных исследователей, а также собственного опыта представлены эндокринные последствия терапии злокачественных опухолей центральной нервной системы в детском и подростковом возрасте, обобщены факторы риска развития различных нарушений со стороны эндокринной системы, проанализированы многочисленные причины, влияющие на рост и развитие кости и приводящие к снижению минеральной плотности костной ткани (МПКТ). Отдельное внимание в обзоре уделяется оценке МПКТ в группе пациентов, перенесших онкологическое заболевание в детском и подростковом возрасте и химиолучевую терапию, обсуждаются вопросы диагностики, профилактики и лечения системного остеопороза у детей.

Medulloblastoma is the most common childhood malignant tumor of the posterior cranial fossa. A comprehensive treatment approach, including surgery, polychemotherapy and radiation therapy, inevitably leads to the development of various long-term consequences from the endocrine system, including a negative impact on bone tissue. Reduced linear growth rate, low adult height and low peak bone mass are well-known long-term effects of treatment. Based on data from Russian and foreign researchers, as well as our own experience, this review presents the endocrine consequences of treatment of malignant tumors of the central nervous system in childhood and adolescence, and summarizes the risk factors for various endocrine system disorders, including a decrease in bone mineral density (BMD). The review pays special attention to the assessment of BMD in a group of patients who have had cancer in childhood and adolescence and have undergone complex treatment, as well as the prevention and treatment of osteoporosis in children.

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The authors declare that there are no conflicts of interest present.