References

porozendo

Остеопороз и остеопатии

Osteoporosis and Bone Diseases

2072-26802311-0716

Endocrinology Research Centre

10.14341/osteo12719

porozendo-12719

Research Article

Научный обзор

Review

Влияние дефицита витамина D на состояние зубочелюстной системы: обзорная статья

Vitamin D imbalance effects on dentoalveolar system: a review

https://orcid.org/0000-0003-4388-8911

Дьячкова

Е. Ю.

Diachkova

E. Y.

Дьячкова Екатерина Юрьевна, к.м.н. eLibrary SPIN: 6877-3782

Кафедра хирургической стоматологии Института стоматологии им. Е.В. Боровского

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Ekaterina Y. Diachkova, PhD. eLibrary SPIN: 6877-3782

Department of Dental Surgery of Borovskiy Institute of Dentistry

8-2 Trubetskaya str., Moscow, 119991

secu2003@mail.ru

https://orcid.org/0000-0003-2414-6437

Трифонова

Д. О.

Trifonova

D. O.

Трифонова Дарья Олеговна, студент

Кафедра хирургической стоматологии Института стоматологии им. Е.В. Боровского

Москва

Daria O. Trifonova, student

Department of Dental Surgery of Borovskiy Institute of Dentistry

Moscow

trifonova030897@mail.ru

https://orcid.org/0000-0002-3961-091X

Ибадулаева

М. О.

Ibadulaeva

M. O.

Ибадулаева Мария Олеговна, ординатор

Кафедра эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

Москва

Maria O. Ibadulaeva, resident

Department of Endocrinology №1 of the Sklifosovsky Institute of Clinical Medicine

Moscow

tmo-4509@mail.ru

https://orcid.org/0000-0003-2144-8595

Рунова

Г. Е.

Runova

G. E.

Рунова Гюзель Евгеньевна, д.м.н. eLibrary SPIN: 3639-6932

Кафедра эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

Москва

Guzel E. Runova, MD. eLibrary SPIN: 3639-6932

Department of Endocrinology №1 of the Sklifosovsky Institute of Clinical Medicine

Moscow

Guzelvolkova@yandex.ru

https://orcid.org/0000-0002-3026-6315

Фадеев

В. В.

Fadeyev

V. V.

Фадеев Валентин Викторович, д.м.н., профессор, член-корр. РАН. eLibrary SPIN: 6825-8417

Кафедра эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

Москва

Valentin V. Fadeyev, MD, PhD, Professor, correspondence fellow of Russian Academy of Sciences. eLibrary SPIN: 6825-8417

Department of Endocrinology №1 of the Sklifosovsky Institute of Clinical Medicine

Moscow

walfad@mail.ru

https://orcid.org/0000-0001-8595-8864

Тарасенко

С. В.

Tarasenko

S. V.

Тарасенко Светлана Викторовна, д.м.н., профессор. eLibrary SPIN: 3320-0052

Кафедра хирургической стоматологии Института стоматологии им. Е.В. Боровского

Москва

Svetlana V. Tarasenko, MD, Professor. eLibrary SPIN: 3320-0052

Department of Dental Surgery of Borovskiy Institute of Dentistry

Moscow

prof_tarasenko@rambler.ru

ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)РоссияFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation

2021

24082021

2411925

2021

Дьячкова Е.Ю., Трифонова Д.О., Ибадулаева М.О., Рунова Г.Е., Фадеев В.В., Тарасенко С.В.

Diachkova E.Y., Trifonova D.O., Ibadulaeva M.O., Runova G.E., Fadeyev V.V., Tarasenko S.V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.osteo-endojournals.ru/jour/article/view/12719

Витамин D принадлежит к группе жирорастворимых секостероидов, играющих важную роль в организме человека. Его основными природными формами являются витамин D3 (холекальциферол) и витамин D2 (эргокальциферол). Их наиболее изученные функции — регуляция фосфорно-кальциевого обмена и обеспечение адекватного ремоделирования костной ткани. Исследования последних лет выявили также и «внекостные» эффекты витамина D, что позволило убедиться в более широкой роли данного соединения. Участие активных форм витамина D в процессах иммуномодуляции, оказание противовоспалительного, антимикробного, антипролиферативного эффектов и стимуляция клеточной дифференцировки отражаются и на заболеваниях челюстно-лицевой области.

В этой статье мы рассмотрели основные функции витамина D в организме человека, «внекостные» эффекты, механизмы его действия и влияние данных процессов на возникновение и течение заболеваний полости рта. Выявление взаимосвязи дефицита витамина D и процессов остеоинтеграции, костного ремоделирования, тяжести течения хронического рецидивирующего афтозного стоматита, плоскоклеточной карциномы и пародонтита позволило сделать вывод о целесообразности своевременной диагностики дефицита витамина D и коррекции его уровня в сыворотке крови у стоматологических больных.

Vitamin D is a fat-soluble secosteroid that plays an important role in the human body. There are two main native forms – vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). The regulation of calcium-phosphate metabolism and ensuring adequate bone remodeling are the most studied function of vitamin D. In recent years, researchers have found out the «extra-bone» effects of vitamin D and it allows us to be convinced of the great role of this compound. The participation of active forms of vitamin D in the processes of immunomodulation, anti-inflammatory, antimicrobial, antiproliferative effects and stimulation of cell differentiation are reflected in diseases of the maxillofacial region.

In this article, we examined the main functions of vitamin D in the human body, the mechanisms of its action and influence on the occurrence and course of oral diseases. The discovery of the relationship between vitamin D deficiency and the processes of osseointegration, bone remodeling, the severity of chronic recurrent aphthous stomatitis, squamous cell carcinoma and periodontitis allow us to conclude that it is advisable to diagnose vitamin D deficiency in appropriate time and correction its serum level in dental patients.

дефицит витамина Dостеоинтеграциядентальная имплантацияпародонтитслизистая полости рта

vitamin D deficiencyosseointegrationdental implantationperiodontitisoral mucosa

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The authors declare that there are no conflicts of interest present.