<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">porozendo</journal-id><journal-title-group><journal-title xml:lang="ru">Остеопороз и остеопатии</journal-title><trans-title-group xml:lang="en"><trans-title>Osteoporosis and Bone Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2680</issn><issn pub-type="epub">2311-0716</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/osteo13186</article-id><article-id custom-type="elpub" pub-id-type="custom">porozendo-13186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Радиочастотная эхографическая мультиспектрометрия (REMS): описание метода и перспективы его использования в клинической практике</article-title><trans-title-group xml:lang="en"><trans-title>Radiofrequency echographic multi spectrometry (REMS): description of the method and perspective for its usage in clinical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2948-5019</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жданова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdanova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жданова Анастасия Станиславовна, аспирант</p><p>117036, г. Москва, ул. Дм. Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Anastasiia S. Zhdanova, PhD student</p><p>117036, Russia, Moscow, Dmitria Uljanova street, 11</p></bio><email xlink:type="simple">npushkareva96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-2805-4460</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Телегина</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Telegina</surname><given-names>M. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Телегина Мария Алексеевна, ординатор</p><p>Москва</p><p>ResearcherID: JMB-6130-2023</p></bio><bio xml:lang="en"><p>Maria А. Telegina</p><p>Moscow</p></bio><email xlink:type="simple">telegina-07@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артемова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Artemova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артемова Алла Михайловна, врач УЗИ-диагностики, заведующий кабинетом ультразвуковой диагностики</p><p>Москва</p></bio><bio xml:lang="en"><p>Alla M. Artemova, ultrasound doctor</p><p>Moscow</p></bio><email xlink:type="simple">alartymova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6674-6441</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белая</surname><given-names>Ж. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Belaya</surname><given-names>Zh. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белая Жанна Евгеньевна, д.м.н., профессор, доктор медицинских наук, заведующая отделением остеопороза и остеопатии отдела терапевтической эндокринологии, профессор кафедры эндокринологии института высшего и дополнительного профессионального образования</p><p>Москва</p></bio><bio xml:lang="en"><p>Zhanna E. Belaya, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">jannabelaya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Endocrinology Research Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>05</month><year>2025</year></pub-date><volume>28</volume><issue>1</issue><fpage>21</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жданова А.С., Телегина М.А., Артемова А.М., Белая Ж.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Жданова А.С., Телегина М.А., Артемова А.М., Белая Ж.Е.</copyright-holder><copyright-holder xml:lang="en">Zhdanova A.S., Telegina M.А., Artemova A.M., Belaya Z.E.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.osteo-endojournals.ru/jour/article/view/13186">https://www.osteo-endojournals.ru/jour/article/view/13186</self-uri><abstract><p>Остеопороз — системное заболевание скелета, характеризующееся снижением костной массы и изменением микроархитектоники ткани. Возникновение низкотравматических переломов вследствие остеопороза приводит к снижению качества и продолжительности жизни старшего населения, а также к увеличению затрат здравоохранения на лечение и реабилитацию данных пациентов, что делает остеопороз медико-социальной проблемой XXI века. Помимо профилактики и лечения, важное значение имеет ранняя и полноценная диагностика остеопороза для инициирования своевременной терапии. Наряду с существующими методами диагностики остеопороза до развития перелома: оценка риска патологических переломов (FRAX), измерение минеральной плотности кости (МПК) двухэнергетической рентгеновской остеоденситометрией (DXA), постоянно развиваются новые технологии, в том числе учитывающие низкую доступность и малую мобильность DXA. Инновационным методом оценки плотности костной ткани и риска переломов является радиочастотная эхографическая мультиспектрометрия — неионизирующий метод сканирования осевых участков скелета — позвоночника и бедра. Настоящий обзор суммирует проведенные исследования и накопленные знания по использованию REMS в клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and changes in tissue microarchitecture. The occurrence of post-traumatic fractures due to osteoporosis leads to a decrease in the quality and life expectancy of the affected population, as well as to an increase in health care costs for the treatment and rehabilitation of these patients, which makes osteoporosis a medical and social problem of the 21st century. In addition to prevention, early and complete diagnosis of osteoporosis is crucial for the initiation of timely treatment. Along with existing methods for osteoporosis diagnostics before a fracture develops: fracture risk assessment (FRAX) and bone mineral density (BMD) measurement by dual-energy X-ray osteodensitometry (DXA), new technologies are constantly being developed, including those that take into account the low availability and low mobility of DXA. An innovative method for assessing bone density and the risk of fractures is radiofrequency echographic multi spectrometry (REMS) - a non-ionizing method for scanning axial areas of the skeleton - the spine and hip. This review summarizes the studies conducted and accumulated knowledge on the use of REMS in clinical practice</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеопороз</kwd><kwd>патологический перелом</kwd><kwd>методы диагностики</kwd><kwd>DXA</kwd><kwd>FRAX</kwd><kwd>REMS</kwd><kwd>минеральная плотность кости</kwd><kwd>радиочастотная эхография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoporosis</kwd><kwd>pathological fractures</kwd><kwd>diagnostic methods</kwd><kwd>DXA</kwd><kwd>FRAX</kwd><kwd>REMS</kwd><kwd>bone mineral density</kwd><kwd>radiofrequency echography</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Работа выполнена в рамках государственного задания №124020700097-8.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hernlund E, Svedbom A, Ivergård M, et al. Osteoporosis in the European Union: a compendium of aetiology, diagnosis and management. Archives of Osteoporosis. 2013;8(1):1-36. doi: https://doi.org/10.1007/s11657-013-0159-0</mixed-citation><mixed-citation xml:lang="en">Hernlund E, Svedbom A, Ivergård M, et al. Osteoporosis in the European Union: a compendium of aetiology, diagnosis and management. Archives of Osteoporosis. 2013;8(1):1-36. doi: https://doi.org/10.1007/s11657-013-0159-0</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings SR, Melton LJ. Epidemiology and Outcomes of Osteoporotic Fractures. The Lancet. 2002;359(9319):1761-1767. doi: https://doi.org/10.1016/S0140-6736(02)08657-9</mixed-citation><mixed-citation xml:lang="en">Cummings SR, Melton LJ. Epidemiology and Outcomes of Osteoporotic Fractures. The Lancet. 2002;359(9319):1761-1767. doi: https://doi.org/10.1016/S0140-6736(02)08657-9</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк О.М., Ершова О.Б., Белова К.Ю и др. Эпидемиология остеопоротических переломов в Российской Федерации и российская модель FRAX. // Остеопороз и остеопатии. — 2014. — Т.17. — №3. — С. 3-8.</mixed-citation><mixed-citation xml:lang="en">Lesnyak OM, Yershova OB, Belova KYu, et al. Еpidemiology of osteoporotic fractures in the russian federation and the russian model of FRAX. Osteoporosis and Bone Diseases. 2014;17(3):3-8. (In Russ.) doi: https://doi.org/10.14341/osteo201433-8</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Белая Ж.Е., Белова К.Ю., Бирюкова Е.В. и др. Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза. // Остеопороз и остеопатии. — 2021. — Т.24. — №2. — С.4-47.</mixed-citation><mixed-citation xml:lang="en">Belaya ZhE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4-47. (In Russ.) doi: https://doi.org/10.14341/osteo12930</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Шарашкина Н.В., Наумов А.В., Дудинская Е.Н. и др. Консенсус экспертов: Диагностика остеопороза и саркопении у пациентов пожилого и старческого возраста. // Терапия. — 2023. — №10. — С.7-20.</mixed-citation><mixed-citation xml:lang="en">Sharashkina NV, Naumov AV, Dudinskaya EN, et al. Consensus of experts: Diagnosis of osteoporosis and sarcopenia in elderly and senile patients. Therapy. (In Russ.) doi: https://doi.org/10.18565/therapy.2023.10.7-20</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Belaya Z, Rozhinskaya L, Dedov I, et al. A summary of the Russian clinical guidelines on the diagnosis and treatment of osteoporosis. Osteoporos International. 2023;34(3):429-447. doi: https://doi.org/10.1007/s00198-022-06667-6</mixed-citation><mixed-citation xml:lang="en">Belaya Z, Rozhinskaya L, Dedov I, et al. A summary of the Russian clinical guidelines on the diagnosis and treatment of osteoporosis. Osteoporos International. 2023;34(3):429-447. doi: https://doi.org/10.1007/s00198-022-06667-6</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sarecka-Hujar B. The Role of DXA in the Assessment of Bone Mineral Density. Wiadomości Lekarskie. 2016;69(1):57-63</mixed-citation><mixed-citation xml:lang="en">Sarecka-Hujar B. The Role of DXA in the Assessment of Bone Mineral Density. Wiadomości Lekarskie. 2016;69(1):57-63</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Beck T. Measuring the structural strength of bones with dualenergy X-ray absorptiometry: principles, technical limitations, and future possibilities. Osteoporos International. 2003;14(5):81–8. doi: https://doi.org/10.1007/s00198-003-1478-0</mixed-citation><mixed-citation xml:lang="en">Beck T. Measuring the structural strength of bones with dualenergy X-ray absorptiometry: principles, technical limitations, and future possibilities. Osteoporos International. 2003;14(5):81–8. doi: https://doi.org/10.1007/s00198-003-1478-0</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Петряйкин А.В., Низовцова Л.А., Артюкова З.Р. и др. Остеоденситометрия: методические рекомендации. Серия «Лучшие практики лучевой и инструментальной диагностики». — Вып. 88. — 2-е изд., перераб. и доп. М.: ГБУЗ «НПКЦ дит ДЗМ»; 2020; 60.</mixed-citation><mixed-citation xml:lang="en">Petryaykin AV, Nizovtsova LA, Artyukova ZR, et al. Osteodensitometry: methodological recommendations. The series «The best practices of radiation and instrumental diagnostics». Issue 88. 2nd ed., reprint. And additional information: GBUZ «NPCC dit DZM». 2020; 60 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis JA, Johnell O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos International. 16(3):229– 238. doi: https://doi.org/10.1007/s00198-004-1811-25</mixed-citation><mixed-citation xml:lang="en">Kanis JA, Johnell O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos International. 16(3):229– 238. doi: https://doi.org/10.1007/s00198-004-1811-25</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк О.М., Баранова И.А., Белова К.Ю. и др. Остеопороз в Российской Федерации: эпидемиология, медико-социальные и экономические аспекты проблемы (обзор литературы). // Травматология и ортопедия России. — 2018Т. 24. — №1 — С.155–168.</mixed-citation><mixed-citation xml:lang="en">Lesnyak OM, Baranova IA, Belova KYu, et al. Osteoporosis in Russian Federation: Epidemiology, Socio-Medical and Economical Aspects (Review). Travmatologiya i ortopediya Rossii [Traumatology and orthopedics of russia. 2018;24(1):155-168. (in Russ). doi: https://doi.org/10.21823/2311-2905-2018-24-1-155-168</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nicholas R Fuggle, Elizabeth M Curtis, Kate A Ward et al. Fracture prediction, imaging and screening in osteoporosis. Nature Reviews Endocrinology. 2019;(15):535–547. doi: https://doi.org/10.1038/s41574-019-0220-8</mixed-citation><mixed-citation xml:lang="en">Nicholas R Fuggle, Elizabeth M Curtis, Kate A Ward et al. Fracture prediction, imaging and screening in osteoporosis. Nature Reviews Endocrinology. 2019;(15):535–547. doi: https://doi.org/10.1038/s41574-019-0220-8</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Diez-Perez A, Brandi ML, Al-Daghri N, et al. Radiofrequency echographic multispectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO). Aging Clin Exp Res. 2019;(31):1375–1389. doi: https://doi.org/10.1007/s40520-019-01294-4</mixed-citation><mixed-citation xml:lang="en">Diez-Perez A, Brandi ML, Al-Daghri N, et al. Radiofrequency echographic multispectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO). Aging Clin Exp Res. 2019;(31):1375–1389. doi: https://doi.org/10.1007/s40520-019-01294-4</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Conversano F, Franchini R, Greco A, et al. A novel ultrasound methodology for estimating spine mineral density. Ultrasound Med. Biol. 2015;41(1):281–300. doi: https://doi.org/10.1016/j.ultrasmedbio.2014.08.017</mixed-citation><mixed-citation xml:lang="en">Conversano F, Franchini R, Greco A, et al. A novel ultrasound methodology for estimating spine mineral density. Ultrasound Med. Biol. 2015;41(1):281–300. doi: https://doi.org/10.1016/j.ultrasmedbio.2014.08.017</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Casciaro S, Peccarisi M, Pisani P, et al. An advanced quantitative echosound methodology for femoral neck densitometry. Ultrasound Med. Biol. 2016;42(60):1337–1356. doi: https://doi.org/10.1016/j.ultrasmedbio.2016.01.024</mixed-citation><mixed-citation xml:lang="en">Casciaro S, Peccarisi M, Pisani P, et al. An advanced quantitative echosound methodology for femoral neck densitometry. Ultrasound Med. Biol. 2016;42(60):1337–1356. doi: https://doi.org/10.1016/j.ultrasmedbio.2016.01.024</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Casciaro S, Conversano F, Pisani P, et al. New perspectives in echographic diagnosis of osteoporosis on hip and spine. Clin. Cases Miner. Bone Metab. 2015;12(2):142–150. doi: https://doi.org/10.11138/ccmbm/2015.12.2.142</mixed-citation><mixed-citation xml:lang="en">Casciaro S, Conversano F, Pisani P, et al. New perspectives in echographic diagnosis of osteoporosis on hip and spine. Clin. Cases Miner. Bone Metab. 2015;12(2):142–150. doi: https://doi.org/10.11138/ccmbm/2015.12.2.142</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк О.М. Новый метод оценки прочности костной ткани: радиочастотная эхографическая мультиспектрометрия. // Эффективная фармакотерапия. — 2020. — Т.16. — №19. — С. 38–44.</mixed-citation><mixed-citation xml:lang="en">Lesnyak OM. A new method for assessing bone tissue strength: radiofrequency echographic multispectrometry. Effective pharmacotherapy. 2020;16(19):38-44. (In Russ.) doi: https://doi.org/10.33978/2307-3586-2020-16-19-38-44</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Caffarelli C, Tomai Pitinica MD, Francolini V, et al. REMS technique: future perspectives in an Academic Hospital. Clin. Cases Miner. Bone Metab. 2018;15(2):163–165. doi: https://doi.org/10.11138/ccmbm/2018.15.2.163</mixed-citation><mixed-citation xml:lang="en">Caffarelli C, Tomai Pitinica MD, Francolini V, et al. REMS technique: future perspectives in an Academic Hospital. Clin. Cases Miner. Bone Metab. 2018;15(2):163–165. doi: https://doi.org/10.11138/ccmbm/2018.15.2.163</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Greco A, Pisani P, Conversano F, Soloperto G. Ultrasound fragility score: an innovative approach for the assessment of bone fragility. Measurement. 2017;101:236–242. doi: https://doi.org/10.1016/j.measurement.2016.01.033</mixed-citation><mixed-citation xml:lang="en">Greco A, Pisani P, Conversano F, Soloperto G. Ultrasound fragility score: an innovative approach for the assessment of bone fragility. Measurement. 2017;101:236–242. doi: https://doi.org/10.1016/j.measurement.2016.01.033</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pisani P, Greco A, Conversano F, et al. A quantitative ultrasound approach to estimate bone fragility: a first comparison with dual X-ray absorptiometry. Measurement. 2017;101:243–249. doi: https://doi.org/10.1016/j.измерение.2016.07.033</mixed-citation><mixed-citation xml:lang="en">Pisani P, Greco A, Conversano F, et al. A quantitative ultrasound approach to estimate bone fragility: a first comparison with dual X-ray absorptiometry. Measurement. 2017;101:243–249. doi: https://doi.org/10.1016/j.измерение.2016.07.033</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Иванов С.Н. REMS — денситометрия. Расширение возможностей диагностики и прогнозирования рисков переломов. // Opinion Leader. — 2021. — Т.45. — №4 — С.78-87.</mixed-citation><mixed-citation xml:lang="en">Ivanov SN. REMS — densitometry. Expanding the possibilities of diagnosing and predicting fracture risks. Opinion Leader. 2021;45(№4)78-87. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sergio Casciaro, Marco Peccarisi , Paola Pisan, et al. An Advanced Quantitative Echosound Methodology for Femoral Neck Densitometry. Ultrasound in Medicine Biology. 2016;42(6):1337-56. doi: https://doi.org/10.1016/j.ultrasmedbio.2016.01.024</mixed-citation><mixed-citation xml:lang="en">Sergio Casciaro, Marco Peccarisi , Paola Pisan, et al. An Advanced Quantitative Echosound Methodology for Femoral Neck Densitometry. Ultrasound in Medicine Biology. 2016;42(6):1337-56. doi: https://doi.org/10.1016/j.ultrasmedbio.2016.01.024</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Cortet B, Dennison E, Diez-Perez A, et al. Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context. Bone. 2021. doi: https://doi.org/10.1016/j.bone.2020.115786</mixed-citation><mixed-citation xml:lang="en">Cortet B, Dennison E, Diez-Perez A, et al. Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context. Bone. 2021. doi: https://doi.org/10.1016/j.bone.2020.115786</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Adami G, Arioli G, Bianchi G, et al. Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study. Bone. 2020;134:115297. doi: https://doi.org/10.1016/j.bone.2020.115297</mixed-citation><mixed-citation xml:lang="en">Adami G, Arioli G, Bianchi G, et al. Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study. Bone. 2020;134:115297. doi: https://doi.org/10.1016/j.bone.2020.115297</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Paola Pisani , Francesco Conversano , Maurizio Muratore, et al. Fragility Score: a REMS-based indicator for the prediction of incident fragility fractures at 5 years. Aging Clin Exp Res. 2023;35(4):763-773. doi: https://doi.org/10.1007/s40520-023-02358-2</mixed-citation><mixed-citation xml:lang="en">Paola Pisani , Francesco Conversano , Maurizio Muratore, et al. Fragility Score: a REMS-based indicator for the prediction of incident fragility fractures at 5 years. Aging Clin Exp Res. 2023;35(4):763-773. doi: https://doi.org/10.1007/s40520-023-02358-2</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">M Di Paola, D Gatti, O Viapiana, et al. Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck. Osteoporos Int. 2019;30(2):391-402. doi: https://doi.org/10.1007/s00198-018-4686-3</mixed-citation><mixed-citation xml:lang="en">M Di Paola, D Gatti, O Viapiana, et al. Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck. Osteoporos Int. 2019;30(2):391-402. doi: https://doi.org/10.1007/s00198-018-4686-3</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lalli P, Claudia Mautino, Chiara Busso, et al. Reproducibility and accuracy of the Radiofrequency Echographic Multi-spectrometry for femoral Mineral density estimation and discriminative power of the femoral fragility score in patients with primary and disuse-related osteoporosis. J Clin Med 2022; 11(13):3761. doi: https://doi.org/10.3390/jcm11133761</mixed-citation><mixed-citation xml:lang="en">Lalli P, Claudia Mautino, Chiara Busso, et al. Reproducibility and accuracy of the Radiofrequency Echographic Multi-spectrometry for femoral Mineral density estimation and discriminative power of the femoral fragility score in patients with primary and disuse-related osteoporosis. J Clin Med 2022; 11(13):3761. doi: https://doi.org/10.3390/jcm11133761</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Picke AK, Campbell G, Napoli N, et al. Update on the Impact of Type 2 Diabetes Mellitus on Bone Metabolism and Material Properties. Endocr Connect. 2019;8(3):55–70. doi: https://doi.org/10.1530/EC-18-0456</mixed-citation><mixed-citation xml:lang="en">Picke AK, Campbell G, Napoli N, et al. Update on the Impact of Type 2 Diabetes Mellitus on Bone Metabolism and Material Properties. Endocr Connect. 2019;8(3):55–70. doi: https://doi.org/10.1530/EC-18-0456</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Carla Caffarelli , Maria Dea Tomai Pitinca , Antonella Al Refaie. Ability of radiofrequency echographic multispectrometry to identify osteoporosis status in elderly women with type 2 diabetes. Aging clinical and experimental research. 2022;34(1):121-127. doi: https://doi.org/10.1007/s40520-021-01889-w</mixed-citation><mixed-citation xml:lang="en">Carla Caffarelli , Maria Dea Tomai Pitinca , Antonella Al Refaie. Ability of radiofrequency echographic multispectrometry to identify osteoporosis status in elderly women with type 2 diabetes. Aging clinical and experimental research. 2022;34(1):121-127. doi: https://doi.org/10.1007/s40520-021-01889-w</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorella Anna Lombardi, Paola Pisani, Francesco Conversano. REMS technology for the assessment of the effect of dmt2 on bone health. Annals of the Rheumatic Diseases. 2024;83:1399-1399. doi: https://doi.org/10.1136/annrheumdis-2024-eular.2241</mixed-citation><mixed-citation xml:lang="en">Fiorella Anna Lombardi, Paola Pisani, Francesco Conversano. REMS technology for the assessment of the effect of dmt2 on bone health. Annals of the Rheumatic Diseases. 2024;83:1399-1399. doi: https://doi.org/10.1136/annrheumdis-2024-eular.2241</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rolla M, Halupczok-Zyła J, Jawiarczyk-Przybyłowska A, et al. Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients. Endokrynol. Pol. 2020;71:524–531. doi: https://doi.org/10.5603/EP.a2020.0056</mixed-citation><mixed-citation xml:lang="en">Rolla M, Halupczok-Zyła J, Jawiarczyk-Przybyłowska A, et al. Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients. Endokrynol. Pol. 2020;71:524–531. doi: https://doi.org/10.5603/EP.a2020.0056</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Adami Giovanni, Brandi Maria Luisa, Caffarelli Carla. Bone health status evaluation in men by means of REMS technology. Aging clinical and experimental research. 2024;36(1):74. doi: https://doi.org/10.1007/s40520-024-02728-4</mixed-citation><mixed-citation xml:lang="en">Adami Giovanni, Brandi Maria Luisa, Caffarelli Carla. Bone health status evaluation in men by means of REMS technology. Aging clinical and experimental research. 2024;36(1):74. doi: https://doi.org/10.1007/s40520-024-02728-4</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Adolfo Diez-Perez , Maria Luisa Brandi , Nasser Al-Daghri. Radiofrequency echographic multi-spectrometry for the invivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Aging clinical and experimental research. 2019;31 (10): 1375-1389. doi: https://doi.org/10.1007/s40520-019-01294-4</mixed-citation><mixed-citation xml:lang="en">Adolfo Diez-Perez , Maria Luisa Brandi , Nasser Al-Daghri. Radiofrequency echographic multi-spectrometry for the invivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Aging clinical and experimental research. 2019;31 (10): 1375-1389. doi: https://doi.org/10.1007/s40520-019-01294-4</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
