porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo13198porozendo-13198Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯCLINICAL GUIDELINESВзаимосвязь между минеральной плотностью костной ткани, трабекулярным костным индексом и уровнем мочевой кислоты у женщин в постменопаузе с ревматоидным артритомRelationship between bone mineral density, trabecular bone score and uric acid level in postmenopausal women with rheumatoid arthritishttps://orcid.org/0000-0003-0560-3495КозыреваМ. В.KozyrevaM. V.

Козырева Мария Витальевна - м.н.с. лаборатории остеопороза.

115522, Москва, Каширское ш., д. 34А

ResearcherID HHZ-3451-2022

Maria V. Kozyreva – MD.

34A, Kashirskoye sh., Moscow, 115522

ResearcherID HHZ-3451-2022

doginya@yandex.ruhttps://orcid.org/0000-0002-2809-0197ДобровольскаяО. В.DobrovolskayaO. V.

Добровольская Ольга Валерьевна - к.м.н., н.с. лаборатории остеопороза.

115522, Москва, Каширское ш., д. 34А

ResearcherID AAF-2921-2021; Scopus Author ID 57197823569

Olga V. Dobrovolskaya - MD, PhD.

34A, Kashirskoye sh., Moscow, 115522

ResearcherID AAF-2921-2021; Scopus Author ID 57197823569

olgavdobr@mail.ruhttps://orcid.org/0000-0001-6759-8367НикитинскаяО. А.NikitinskayaO. A.

Никитинская Оксана Анатольевна - к.м.н., начальник отдела координации научной деятельности, ученый секретарь ФГБНУ НИИР им. В.А. Насоновой.

115522, Москва, Каширское ш., д. 34А

ResearcherID AAF-2616-2021; Scopus Author ID 6504217119

Oksana A. Nikitinskaya - MD, PhD.

34A, Kashirskoye sh., Moscow, 115522

ResearcherID AAF-2616-2021; Scopus Author ID 6504217119

nikitinskaya@niir.suhttps://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

Торопцова Наталья Владимировна - д.м.н., заведующий лабораторией остеопороза.

115522, Москва, Каширское ш., д. 34А

ResearcherID I-9030-2017; Scopus Author ID 6507457856

Natalia V. Toroptsova - MD, PhD.

34A, Kashirskoye sh., Moscow, 115522

ResearcherID I-9030-2017; Scopus Author ID 6507457856

torop@irramn.ruФГБНУ «Научно-исследовательский институт ревматологии имени В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202531082025282410Copyright © Козырева М.В., Добровольская О.В., Никитинская О.А., Торопцова Н.В., 20252025Козырева М.В., Добровольская О.В., Никитинская О.А., Торопцова Н.В.Kozyreva M.V., Dobrovolskaya O.V., Nikitinskaya O.A., Toroptsova N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/13198Обоснование

Обоснование. Мочевая кислота (МК) конечный продукт пуринового обмена у людей. МК рассматривается как антиоксидант, который предотвращает негативные эффекты окислительного стресса, связанного со старением и метаболическими заболеваниями. В некоторых исследованиях показаны как положительные, так и отрицательные ассоциации между МК и минеральной плотностью кости (МПК), а ее взаимосвязь с показателем трабекулярного костного индекса (ТКИ) не до конца изучена.

Цель

Цель. Определить взаимосвязь МПК и ТКИ с уровнем МК у женщин в постменопаузе с ревматоидным артритом (РА).

Материалы и методы

Материалы и методы. В одномоментное исследование включены 140 женщин (медиана возраста 65,0 [59,5; 70,0] лет) в постменопаузе с достоверным диагнозом РА. Проведено анкетирование по унифицированному опроснику, лабораторное обследование, выполнена двухэнергетическая рентгеновская абсорбциометрия поясничного отдела позвоночника (L1–L4) с определением трабекулярного костного индекса (ТКИ) и проксимального отдела бедра (ПОБ).

Результаты

Результаты. В обследованной группе деградированная микроархитектоника по ТКИ выявлена у 40,7% пациентов, а среднее значение МК составило 273,9±73,7 мкмоль/л. При корреляционном анализе уровня МК с МПК различных областей измерения и ТКИ выявлена положительная ассоциация между ним и МПК L1–L4 (r=0,025, p=0,003), МПК ПОБ в целом (r=0,23, p=0,007), МПК шейки бедра (ШБ) и негативная — с ТКИ (r=-0,18, p=0,035). В результате множественной линейной регрессии установлена значимая положительная ассоциация МПК L1–L4 и ПОБ в целом с МК и индексом массы тела (ИМТ), отрицательная — МПК ПОБ в целом и ТКИ с возрастом и уровня МК с ТКИ, в то время как МПК ШБ негативно связана с возрастом и позитивно — с ИМТ и приемом кальция, а с МК взаимосвязь не выявлена.

Заключение

Заключение. Наше исследование показало разнонаправленную взаимосвязь уровня МК с МПК и ТКИ у постменопаузальных женщин с РА: положительную — с МПК позвоночника и ПОБ в целом, негативную — с ТКИ.

Background

Background: uric acid (UA) is the end product of purine metabolism in humans. UA is considered as an antioxidant that prevents the negative effects of oxidative stress associated with aging and metabolic diseases. Some studies have shown both positive and negative associations between UA and bone mineral density (BMD) and its relationship with the trabecular bone score (TBS) is not fully understood.

Aim

Aim: to determine the relationship of BMD and TBS with UA level in postmenopausal women with rheumatoid arthritis (RA).

Materials and methods

Materials and methods: the cross-sectional study included 140 postmenopausal women (median age 65.0 [59.5; 70.0] years) with a reliable diagnosis of RA. A unified questionnaire survey was conducted, a laboratory examination and dual-energy X-ray absorptiometry of femur and lumbar spine (L1-L4) with determination of TBS were performed.

Results

Results: in the examined group, degraded microarchitecture was detected in 40.7% of patients, and the mean UA level was 273.9±73.7 mmol/L. Correlation analysis revealed a positive association between UA level and BMD of L1-L4 (r=0.025, p=0.003), total hip (TH) (r=0.23, p=0.007) and femoral neck (FN) (r=0,15, p=0,045) and a negative association with TBS (r=-0.18, p=0.035). Multiple linear regression revealed a significant positive association between BMD L1-L4 and TH with UA and body mass index (BMI), a negative association of BMD TH and TBS with age and UA level with TBS, while BMD FN was negatively associated with age and positively associated with BMI and calcium intake, but no relationship has been identified with UA.

Conclusion

Conclusion: our study showed an independent multidirectional relationship of UA level with BMD and TBS in postmenopausal women with RA: positive — with BMD L1-L4 and TH, negative — with TBS.

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The authors declare that there are no conflicts of interest present.