porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo13200porozendo-13200Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWSСовременные подходы к оценке костных нарушений при первичном гиперпаратиреозе: потенциал 3D-моделирования бедренной костиModern approaches to assessing bone disorders in primary hyperparathyroidism: the potential of 3D-modeling of the femurhttps://orcid.org/0000-0002-9462-8522Першина-МилютинаА. П.Pershina-MiliutinaA. P.

Першина-Милютина Анастасия Павловна.

117036, Москва, улица Дм. Ульянова, д. 11

Anastasiia P. Pershina-Miliutina - MD.

11 Dm. Ulyanova street, 117036 Moscow

oa11111998@gmail.comhttps://orcid.org/0000-0001-6667-062XЕремкинаА. К.EremkinaA. K.

Еремкина Анна Константиновна - к.м.н.

Москва

Anna K. Eremkina - MD, PhD.

Moscow

eremkina.anna@endocrincentr.ruhttps://orcid.org/0009-0007-1336-4152АредовА. В.AredovA. V.

Аредов Алексей Вячеславович.

Москва

Aleksey V. Aredov.

Moscow

aredov.aleksey@endocrincentr.ruhttps://orcid.org/0000-0002-3118-1401ОжималовИ. Д.OzhimalovI. D.

Ожималов Илья Дмитриевич.

Москва

Ilia D. Ozhimalov.

Moscow

i.ozhimalov@gmail.comhttps://orcid.org/0000-0003-2669-9457ГорбачеваА. М.GorbachevaA. M.

Горбачева Анна Максимовна.

Москва

Anna M. Gorbacheva - MD, PhD.

Moscow

gorbacheva.anna@endocrincentr.ruhttps://orcid.org/0000-0002-6758-5918ХайриеваА. В.KhairievaA. V.

Хайриева Ангелина Владимировна.

Москва

Angelina V. Khairieva - MD.

Moscow

komarito@mail.ruhttps://orcid.org/0000-0001-7965-9454ТарбаеваН. В.TarbaevaN. V.

Тарбаева Наталья Викторовна - к.м.н.

Москва

Natalia V. Tarbaeva - MD, PhD.

Moscow

ntarbaeva@inbox.ruhttps://orcid.org/0000-0002-9717-9742МокрышеваН. Г.MokryshevaN. G.

Мокрышева Наталья Георгиевна - д.м.н., профессор.

Москва

Natalia G. Mokrysheva - MD, PhD, Professor.

Moscow

mokrisheva.natalia@endocrincentr.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian FederationМосковский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation2025310820252821118Copyright © Першина-Милютина А.П., Еремкина А.К., Аредов А.В., Ожималов И.Д., Горбачева А.М., Хайриева А.В., Тарбаева Н.В., Мокрышева Н.Г., 20252025Першина-Милютина А.П., Еремкина А.К., Аредов А.В., Ожималов И.Д., Горбачева А.М., Хайриева А.В., Тарбаева Н.В., Мокрышева Н.Г.Pershina-Miliutina A.P., Eremkina A.K., Aredov A.V., Ozhimalov I.D., Gorbacheva A.M., Khairieva A.V., Tarbaeva N.V., Mokrysheva N.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/13200

Первичный гиперпаратиреоз (ПГПТ) является распространенным эндокринным заболеванием, сопровождающимся избыточной секрецией паратиреоидного гормона и нарушением минерального обмена, что приводит к снижению минеральной плотности костной ткани (МПК) и увеличению риска переломов. Для оценки состояния костной системы традиционно используются рентгенография, двухэнергетическая рентгеновская абсорбциометрия (DXA), количественная компьютерная томография (ККТ), периферическая ККТ высокого разрешения и радиочастотная эхографическая мультиспектрометрия (REMS). Однако эти методы имеют определенные ограничения, что обусловливает необходимость поиска новых диагностических подходов. В последние годы активно развивается 3D-моделирование бедренной кости (3D-DXA), позволяющее проводить трехмерный анализ плотности и структуры костной ткани на основе данных DXA. Этот метод демонстрирует высокую точность и корреляцию с ККТ, обеспечивая более детальную оценку изменений в кортикальном и трабекулярном компонентах. Применение 3D-DXA открывает новые перспективы в диагностике и мониторинге костных осложнений при ПГПТ, что может способствовать более точному прогнозированию риска переломов и персонализированному выбору терапевтической тактики.

Primary hyperparathyroidism (PHPT) is a common endocrine disease with excessive secretion of parathyroid hormone and impaired mineral metabolism, resulting in decreased bone mineral density (BMD) and increased fracture risk. Radiography, dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), high-resolution peripheral QCT (HRPQCT) and radiofrequency echographic multispectrometry (REMS) have traditionally been used to assess bone density. However, these methods have certain limitations, therefore the search for new diagnostic approaches is necessary. In recent years, 3D femoral bone modelling (3D-DXA) has been actively developed, which allows three-dimensional analysis of bone density and structure based on DXA data. This method demonstrates high accuracy and correlation with CT, providing a more detailed assessment of changes in the cortical and trabecular components. The use of 3D-DXA opens new perspectives in the diagnosis and monitoring of bone complications in PHPT, which may contribute to more effective fracture risk prediction and personalised choice of therapeutic tactics.

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The authors declare that there are no conflicts of interest present.