porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2011121-26porozendo-4129Research ArticleСтатьиArticlesОжирение и остеопорозObesity and osteoporosisShishkovaV. N.-ShishkovaV. N.-201115042011141№1 (2011)2126Copyright © Shishkova V.N., Shishkova V.N., 20112011Shishkova V.N., Shishkova V.N.Shishkova V.N., Shishkova V.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/4129

Остеопороз и ожирение являются широко распространенными заболеваниями у людей после 50 лет и связаны с изменениями строения и состава тела. Эти болезни определяются как разными генетическими факторами, так и имеют в своей основе изменения общих клеток. С возрастом строение костного мозга изменяется в сторону преобладания адипоцитов, увеличения костно-резорбтивной активности и снижения образования остеобластов, что приводит к остеопорозу. Вторичные причины остеопороза, такие как сахарный диабет, гиперкортицизм, иммобилизация и метаболический синдром, ассоциируются с ожирением костного мозга. Изучение взаимосвязей между костью и жировой тканью на молекулярном и клеточном уровнях может привести к лучшему пониманию механизмов остеопороза и ожирения и разработке лекарств для лечения этих заболеваний.

Osteoporosis and obesity, two disorders of body composition, are growing in prevalence. Interestingly, these diseases share several features including a genetic predisposition and a common progenitor cell. With aging, the composition of bone marrow shifts to favor the presence of adipocytes, osteoclast activity increases, and osteoblast function declines, resulting in osteoporosis. Secondary causes of osteoporosis, including diabetes mellitus, glucocorticoids, immobility and metabolic syndrome are associated with bone-marrow adiposity. Unraveling the interface between bone and fat at a molecular and cellular level is likely to lead to a better understanding of several diseases, and to the development of drugs for both osteoporosis and obesity.

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