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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">porozendo</journal-id><journal-title-group><journal-title xml:lang="ru">Остеопороз и остеопатии</journal-title><trans-title-group xml:lang="en"><trans-title>Osteoporosis and Bone Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2680</issn><issn pub-type="epub">2311-0716</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/osteo2010313-18</article-id><article-id custom-type="elpub" pub-id-type="custom">porozendo-4190</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>ЭПИДЕМИОЛОГИЧЕСКИЕ АСПЕКТЫ ПЕРВИЧНОГОГИПЕРПАРАТИРЕОЗА В РОССИИ</article-title><trans-title-group xml:lang="en"><trans-title>EPIDEMIOLOGIChESKIE ASPEKTY PERVIChNOGOGIPERPARATIREOZA V ROSSII</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Rozhinskaya</surname><given-names>L. Ya.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Rostomyan</surname><given-names>L. G.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Mokrysheva</surname><given-names>N. G.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Mirnaya</surname><given-names>S. S.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Kirdyankina</surname><given-names>N. O.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2010</year></pub-date><volume>13</volume><issue>3</issue><issue-title>№3 (2010)</issue-title><fpage>13</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rozhinskaya L.Y., Rostomyan L.G., Mokrysheva N.G., Mirnaya S.S., Kirdyankina N.O., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Rozhinskaya L.Y., Rostomyan L.G., Mokrysheva N.G., Mirnaya S.S., Kirdyankina N.O.</copyright-holder><copyright-holder xml:lang="en">Rozhinskaya L.Y., Rostomyan L.G., Mokrysheva N.G., Mirnaya S.S., Kirdyankina N.O.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.osteo-endojournals.ru/jour/article/view/4190">https://www.osteo-endojournals.ru/jour/article/view/4190</self-uri><abstract><p>В настоящее время ПГПТ находится на третьем месте по распространенности среди эндокринопатий, и имеет
различные клинические проявления. Внедрение автоматического определения кальция в рутинную практику в Запад-
ной Европе и США позволило диагностировать большое количество пациентов с асимптомным и малосимптомным
течением ПГПТ. К настоящему времени исследований по распространенности первичного гиперпаратиреоза в России
практически нет.
Цель: изучить частоту встречаемости ПГПТ по обращаемости, определить клиническую структуру ПГПТ в
России.
Материалы и методы: в ходе ретроспективного исследования оценивали клинические проявления и лечение паци-
ентов с подтвержденным диагнозом ПГПТ (1995-2010 гг). Данные о пациентах были получены от эндокринологов из 8
регионов РФ. Результаты: собрана информация о 738 пациентах с ПГПТ (ж:м 8:1) в возрасте от 13 до 83,4 лет (сред-
ний возраст 54,3). Из них 54% из Москвы (n=397), 11% из Московской области (n=79) и 35% из 53 регионов РФ (n=262).
Манифестный ПГПТ встречался в 74% случаев (остеопороз выявлен у 56%, мочекаменная болезнь в 45%, язвенная бо-
лезнь у 18% пациентов). Согласно полученным нами данным с 2005 года отмечается увеличение выявляемости ПГПТ,
особенно его мягких форм. Хирургическое лечение ПГПТ проводилось в 64,9% случаев. Повторным операциям на ОЩЖ
подвергались 17 пациентов. Консервативное лечение по поводу ПГПТ (бисфосфонаты, миакальцик, цинакальцет) было
назначено 28,3%. 11,5% пациентов находились под динамическим наблюдением без лечения.
Заключение: в представленной работе анализируются причины поздней выявляемости первичного гиперпарати-
реоза, возрастные и половые характеристики пациентов, динамика эпидемиологических показателей и клинической
структуры ПГПТ с 1995 по 2010 гг. В России преобладают манифстнаые формы ПГПТ с преимущественным пораже-
нием костной ткани и почек.</p></abstract><trans-abstract xml:lang="en"><p>Primary hyperparathyroidism (PHPT) is the third most
frequent endocrine disorder and has a variable clinical
presentation. Asymptomatic PHPT became the predominant
form of the disease with increase of its incidence after the
introduction of automated serum calcium measurement in
North America and Europe. Data from Russia is lacking. Aim:
To present the clinical profile of PHPT in Russia. Materials
and Methods: This retrospective study was conducted at
endocrinology centers in 8 regions of Russia. We analyzed
the clinical presentation, and treatment options in patients
with confirmed PHPT (1995-2010). Results: 738 patients (F:
M-8:1) with age ranging from 13 to 83,4 years (mean 54,3)
were analyzed. 54% was from Moscow (n=397), 11% - from
Moscow region (n=79) and 35% - from 53 regions of Russia
(n=262). Symptomatic PHPT was the most common form (74%)
and was revealed with osteoporosis in 56%, nephrolithiasis - in
45% and ulcer disease - in 18%. Our data showed an increase
in the incidence of PHPT (especially mild PHPT) after 2005
compared with earlier period. 64,9% of patients were treated
surgically, 17 patients undergone repeated parathyroid surgery.
28,3% received bisphosphonates, calcitonin and/or cinacalcet .
11,5% was observed without treatment. Conclusions: This
data analyzes some causes of delayed diagnosis of PHPT in
Russia, characterized age and gender distribution of patients
with PHPT and demonstrates the changes in clinical profile of
disease from 1995 to 2010. PHPT still remains symptomatic
disorder in our country most frequently with skeletal and renal
manifestations.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Выродов К. С., Архипов О. И., Бондаренко А.Г., Цациев Д. А., Пыхтин Ю. Ю. Трудности в диагности- ке и хирургическом лечении первичного гиперпаратиреоза Кубанский научный медицинский вестник. 2009; 9: 20-22</mixed-citation><mixed-citation xml:lang="en">Выродов К. С., Архипов О. И., Бондаренко А.Г., Цациев Д. А., Пыхтин Ю. Ю. Трудности в диагности- ке и хирургическом лечении первичного гиперпаратиреоза Кубанский научный медицинский вестник. 2009; 9: 20-22</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Котова И.В., Калинин А.П., Казанцева И.А. и др. 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