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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">porozendo</journal-id><journal-title-group><journal-title xml:lang="ru">Остеопороз и остеопатии</journal-title><trans-title-group xml:lang="en"><trans-title>Osteoporosis and Bone Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2680</issn><issn pub-type="epub">2311-0716</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/osteo2010337-41</article-id><article-id custom-type="elpub" pub-id-type="custom">porozendo-4195</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>ПРИМЕНЕНИЕ ДЖЕНЕРИКОВ - СПОСОБ ПОВЫШЕНИЯ ПРИВЕРЖЕННОСТИ ЛЕЧЕНИЮ ОСТЕОПОРОЗА</article-title><trans-title-group xml:lang="en"><trans-title>PRIMENENIE DZhENERIKOV - SPOSOB POVYShENIYa PRIVERZhENNOSTI LEChENIYu OSTEOPOROZA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Skripnikova</surname><given-names>I A</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Rozhinskaya</surname><given-names>L Ya</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2010</year></pub-date><volume>13</volume><issue>3</issue><issue-title>№3 (2010)</issue-title><fpage>37</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Skripnikova I.A., Rozhinskaya L.Y., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Skripnikova I.A., Rozhinskaya L.Y.</copyright-holder><copyright-holder xml:lang="en">Skripnikova I.A., Rozhinskaya L.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.osteo-endojournals.ru/jour/article/view/4195">https://www.osteo-endojournals.ru/jour/article/view/4195</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>остеопороз</kwd><kwd>дженерики</kwd><kwd>экономическая эффективность</kwd><kwd>Фороза</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк Ю.Ф. Анализ за- трат при профилактике перелома проксимального отдела бедра, ассоциированного с остеопо- розом. Остеопороз и остеопа- тии.2003. 3: 2-5.</mixed-citation><mixed-citation xml:lang="en">Лесняк Ю.Ф. Анализ за- трат при профилактике перелома проксимального отдела бедра, ассоциированного с остеопо- розом. Остеопороз и остеопа- тии.2003. 3: 2-5.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лялина В.В., Мылов Н.М., Дмитриева Е.Г. и др. Изуче- ние переносимости алендроната 70 мг в неделю и причин отмены лечения у больных постменопаузальным остеопорозом в условиях реальной клинической практики. Остеопороз и остеопатии. 2007. 3:31-35.</mixed-citation><mixed-citation xml:lang="en">Лялина В.В., Мылов Н.М., Дмитриева Е.Г. и др. Изуче- ние переносимости алендроната 70 мг в неделю и причин отмены лечения у больных постменопаузальным остеопорозом в условиях реальной клинической практики. Остеопороз и остеопатии. 2007. 3:31-35.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Марченкова Л., Древаль А., Крюкова И., и др. Оценка медицинской помощи больным остеопорозом по результатам анкетирования врачей московской области. Врач. 2009.11: 95-102.</mixed-citation><mixed-citation xml:lang="en">Марченкова Л., Древаль А., Крюкова И., и др. Оценка медицинской помощи больным остеопорозом по результатам анкетирования врачей московской области. Врач. 2009.11: 95-102.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Рожинская Л.Я., Дзеранова Л.К., Марова Е.И. и др. Ре- зультаты лечения постменопаузального остеопороза бисфосфонатом фосамаксом (алендронатом). Остеопороз и остеопатии. 1998. 2:28-32.</mixed-citation><mixed-citation xml:lang="en">Рожинская Л.Я., Дзеранова Л.К., Марова Е.И. и др. Ре- зультаты лечения постменопаузального остеопороза бисфосфонатом фосамаксом (алендронатом). Остеопороз и остеопатии. 1998. 2:28-32.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по остеопорозу. Под ред. проф.Л.И.Беневоленской. БИНОМ . 2003.10-53.</mixed-citation><mixed-citation xml:lang="en">Руководство по остеопорозу. Под ред. проф.Л.И.Беневоленской. БИНОМ . 2003.10-53.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Скрипникова И.А., Косматова О.В. Результаты лечения постменопаузального остеопороза бисфосфонатом фосамаксом. Остеопороз и остеопатии. 2004.1:16-19.</mixed-citation><mixed-citation xml:lang="en">Скрипникова И.А., Косматова О.В. Результаты лечения постменопаузального остеопороза бисфосфонатом фосамаксом. Остеопороз и остеопатии. 2004.1:16-19.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Скрипникова И.А., Косматова О.В., Новиков В.Е. и др. Результаты открытого многоцентрового исследования эффективности и переносимости фосамакса 70 мг 1 раз в неделю при постменопаузальном остеопорозе. Остеопороз и остеопатии. 2005.3: 34-38.</mixed-citation><mixed-citation xml:lang="en">Скрипникова И.А., Косматова О.В., Новиков В.Е. и др. Результаты открытого многоцентрового исследования эффективности и переносимости фосамакса 70 мг 1 раз в неделю при постменопаузальном остеопорозе. Остеопороз и остеопатии. 2005.3: 34-38.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Торопцова Н.В., Никитинская О.А., Демин Н.В. и др. Результаты изучения эффективности еженедельного приема алендроната (фосамакс® у больных с первичным остеопорозом. Остеопороз и остеопатии. 2006. 1:23-25.</mixed-citation><mixed-citation xml:lang="en">Торопцова Н.В., Никитинская О.А., Демин Н.В. и др. Результаты изучения эффективности еженедельного приема алендроната (фосамакс® у больных с первичным остеопорозом. Остеопороз и остеопатии. 2006. 1:23-25.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Энциклопедический словарь терминов фармаколо- гии, фармакотерапии и фармации. Шварц Г.Я. -М.: Литтерра, 2008. -576 с.</mixed-citation><mixed-citation xml:lang="en">Энциклопедический словарь терминов фармаколо- гии, фармакотерапии и фармации. Шварц Г.Я. -М.: Литтерра, 2008. -576 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Adami S., Baroni M.C., Broggini M., et al. Treatment of postmenopausal osteoporosis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin. Osteoporosis Int. 1993. (Suppl 3):S21-27.</mixed-citation><mixed-citation xml:lang="en">Adami S., Baroni M.C., Broggini M., et al. Treatment of postmenopausal osteoporosis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin. Osteoporosis Int. 1993. (Suppl 3):S21-27.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Black D.M., Cummings S.R., Karpf D.B. et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture intervention Trial Research Group. Lancet. 1996.348: 1535-41.</mixed-citation><mixed-citation xml:lang="en">Black D.M., Cummings S.R., Karpf D.B. et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture intervention Trial Research Group. Lancet. 1996.348: 1535-41.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Black D.M., Delmas P.D., Eastell R., et al. 2007 Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007. 356(18): 1809-22.</mixed-citation><mixed-citation xml:lang="en">Black D.M., Delmas P.D., Eastell R., et al. 2007 Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007. 356(18): 1809-22.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bock O., Felsenberg D. Bisphosphonates in the management of postmenopausal osteoporosis- optimizing efficacy in clinical practice. Clinical Interven Aging. 2008. 3(2):279-297.</mixed-citation><mixed-citation xml:lang="en">Bock O., Felsenberg D. Bisphosphonates in the management of postmenopausal osteoporosis- optimizing efficacy in clinical practice. Clinical Interven Aging. 2008. 3(2):279-297.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Black D.M., Schwartz A.V., Ensrud K.E. et al. Effect of continuing or stopping alendronate after 5 years of treatment: The fracture intervention trial long-term extension (FLEX): a randomized trial. JAMA. 2006. 296: 2927-38.</mixed-citation><mixed-citation xml:lang="en">Black D.M., Schwartz A.V., Ensrud K.E. et al. Effect of continuing or stopping alendronate after 5 years of treatment: The fracture intervention trial long-term extension (FLEX): a randomized trial. JAMA. 2006. 296: 2927-38.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bonnen S., Laan R.F., Barton I.P., et al. Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies. Osteoporos Int. 2005. 16:1291-8.</mixed-citation><mixed-citation xml:lang="en">Bonnen S., Laan R.F., Barton I.P., et al. Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies. Osteoporos Int. 2005. 16:1291-8.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bone HG, Hosking D., Devogelaer J-P, et al.Ten years experience with Alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004.350: 1189-1199.</mixed-citation><mixed-citation xml:lang="en">Bone HG, Hosking D., Devogelaer J-P, et al.Ten years experience with Alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004.350: 1189-1199.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cranney A., Guyatt G., Griffith L. et al. Meta-analyses of therapies for postmenopausal osteoporosis. IX: Meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev.2002. 23(4): 570-578.</mixed-citation><mixed-citation xml:lang="en">Cranney A., Guyatt G., Griffith L. et al. Meta-analyses of therapies for postmenopausal osteoporosis. IX: Meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev.2002. 23(4): 570-578.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Curtis J.R., Westfall A.O., Cheng H., et al. Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101.038 new bisphosphonate users. J Bone Miner Res. 2008. 23(9): 1435-1441.</mixed-citation><mixed-citation xml:lang="en">Curtis J.R., Westfall A.O., Cheng H., et al. Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101.038 new bisphosphonate users. J Bone Miner Res. 2008. 23(9): 1435-1441.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings S.R., Black D.M., Thompson D.E., et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention trial. JAMA.1998. 280:2077-82.</mixed-citation><mixed-citation xml:lang="en">Cummings S.R., Black D.M., Thompson D.E., et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention trial. JAMA.1998. 280:2077-82.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Chesnut III C.H., Skag A., Christiansen C. et al. Effects of oral ibandronate administered daily or intermittently of fracture risk in postmenopausal osteoporosis. J Bone Miner Res. 2004. 19:1241-9.</mixed-citation><mixed-citation xml:lang="en">Chesnut III C.H., Skag A., Christiansen C. et al. Effects of oral ibandronate administered daily or intermittently of fracture risk in postmenopausal osteoporosis. J Bone Miner Res. 2004. 19:1241-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">De Laet C.E.D.H., van Hout B.A., Burger H. Et al. Incremental Cost of Medical Care after hip fracture and first vertebral fracture: The Rotterdam Study. Osteoporos Int. 1999.10: 66-72.</mixed-citation><mixed-citation xml:lang="en">De Laet C.E.D.H., van Hout B.A., Burger H. Et al. Incremental Cost of Medical Care after hip fracture and first vertebral fracture: The Rotterdam Study. Osteoporos Int. 1999.10: 66-72.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ensrud K, et al. Poster presented at: ECTS/IBMS; 25-29 June 2005; Geneva, Switzerland.</mixed-citation><mixed-citation xml:lang="en">Ensrud K, et al. Poster presented at: ECTS/IBMS; 25-29 June 2005; Geneva, Switzerland.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fleurence R.L., Iglesias C.P., Johnson J.M. The costeffectiveness of bisphosphonates for the prevention and treatment of osteoporosis. Pharmacoeconomics. 2007.25(11):913-933.</mixed-citation><mixed-citation xml:lang="en">Fleurence R.L., Iglesias C.P., Johnson J.M. The costeffectiveness of bisphosphonates for the prevention and treatment of osteoporosis. Pharmacoeconomics. 2007.25(11):913-933.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Francis R.M. Oral bisphosphonates in the treatment of osteoporosis: a review. Current Ther Res. 1995. 56 (9):831-51.</mixed-citation><mixed-citation xml:lang="en">Francis R.M. Oral bisphosphonates in the treatment of osteoporosis: a review. Current Ther Res. 1995. 56 (9):831-51.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Goettsch W,G., Penning F., Erkens J.E., et al. Persistent bisphosphonate usage reduces the risk of hospitalizations for osteoporotic fractures. J Bone Miner Res. 2005. 20 (Suppl 1):S278.</mixed-citation><mixed-citation xml:lang="en">Goettsch W,G., Penning F., Erkens J.E., et al. Persistent bisphosphonate usage reduces the risk of hospitalizations for osteoporotic fractures. J Bone Miner Res. 2005. 20 (Suppl 1):S278.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">International osteoporosis foundation. 2005. IOF adherence gap report. Accessed 10May 2010.www.osteofound. org/publications/pdf/adherence_gap_report.</mixed-citation><mixed-citation xml:lang="en">International osteoporosis foundation. 2005. IOF adherence gap report. Accessed 10May 2010.www.osteofound. org/publications/pdf/adherence_gap_report.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">IMS. Среднерозничные цены в рублях, 1H2010.</mixed-citation><mixed-citation xml:lang="en">IMS. Среднерозничные цены в рублях, 1H2010.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Joness J., Scoot D. Cost-еffectivеness of alendronate for fracture prevention in postmenopausal women. Ashgate. 1999:1058-072.</mixed-citation><mixed-citation xml:lang="en">Joness J., Scoot D. Cost-еffectivеness of alendronate for fracture prevention in postmenopausal women. Ashgate. 1999:1058-072.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Johnell O., Jonsson B., Jonsson l. et al. Cost effectiveness of alendronate (fosamax®) for the treatment of osteoporosis and prevention of fravtures. Pharmacoeconomics.2003.21(5):305-14.</mixed-citation><mixed-citation xml:lang="en">Johnell O., Jonsson B., Jonsson l. et al. Cost effectiveness of alendronate (fosamax®) for the treatment of osteoporosis and prevention of fravtures. Pharmacoeconomics.2003.21(5):305-14.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis J.A. Diagnosis of osteoporosis and assessment of fracture risk. Lancet.2002.359:929- 36.</mixed-citation><mixed-citation xml:lang="en">Kanis J.A. Diagnosis of osteoporosis and assessment of fracture risk. Lancet.2002.359:929- 36.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kothawala P., Badamgarav E., Ryu S., et al. Systematic review and meta-analyses of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007. 82 (12): 1493-1501.</mixed-citation><mixed-citation xml:lang="en">Kothawala P., Badamgarav E., Ryu S., et al. Systematic review and meta-analyses of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007. 82 (12): 1493-1501.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lucman S.P., Hughes D.E., Coxon F.P. et al. Nitrogencontaining bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res.1998. 13: 581-9.</mixed-citation><mixed-citation xml:lang="en">Lucman S.P., Hughes D.E., Coxon F.P. et al. Nitrogencontaining bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res.1998. 13: 581-9.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lin J.H., Chen I.W., Deluna F.A., et al. Role of calcium in plasma protein binding and renal handling of alendronate in hypo and hypercalcemic rats. J Pharmacol Exp Ther. 1993. 267:570-5.</mixed-citation><mixed-citation xml:lang="en">Lin J.H., Chen I.W., Deluna F.A., et al. Role of calcium in plasma protein binding and renal handling of alendronate in hypo and hypercalcemic rats. J Pharmacol Exp Ther. 1993. 267:570-5.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Melton III L.J., Chrischilles E.A.,Cooper C., et al. Perspective: How many women have osteoporosis? J Bone Miner Res. 1992. 7:1005-10.</mixed-citation><mixed-citation xml:lang="en">Melton III L.J., Chrischilles E.A.,Cooper C., et al. Perspective: How many women have osteoporosis? J Bone Miner Res. 1992. 7:1005-10.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">National Osteoporosis Foundation. Osteoporosis: costeffectiveness analysis and review of the evidence for prevention, diagnosis and treatment. Osteoporos Int. 1998, 8 (Suppl.4): S1-S88.</mixed-citation><mixed-citation xml:lang="en">National Osteoporosis Foundation. Osteoporosis: costeffectiveness analysis and review of the evidence for prevention, diagnosis and treatment. Osteoporos Int. 1998, 8 (Suppl.4): S1-S88.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen N.D., AhlborgY.G., Center J.R., et al. Residual lifetime risk of fractures in women and man. J. Bone Miner Res. 2007. 22:781-8.</mixed-citation><mixed-citation xml:lang="en">Nguyen N.D., AhlborgY.G., Center J.R., et al. Residual lifetime risk of fractures in women and man. J. Bone Miner Res. 2007. 22:781-8.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson B., Watts and Dima L. Diab. Long-term use of bisphosphonates in osteoporosis. J Clin Endocrin Metab. 2010. 95(4); 0-0.</mixed-citation><mixed-citation xml:lang="en">Nelson B., Watts and Dima L. Diab. Long-term use of bisphosphonates in osteoporosis. J Clin Endocrin Metab. 2010. 95(4); 0-0.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Reginster L.Y., Burlet N. Osteoporosis: A still increasing prevalence. Bone. 2006. 38:S4-9</mixed-citation><mixed-citation xml:lang="en">Reginster L.Y., Burlet N. Osteoporosis: A still increasing prevalence. Bone. 2006. 38:S4-9</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Reginster J.Y., Rebenda V. Patient preference in the management of postmenopausal osteoporosis with bisphosphonates. Clin IntervAging. 2006. 1: 415-23.</mixed-citation><mixed-citation xml:lang="en">Reginster J.Y., Rebenda V. Patient preference in the management of postmenopausal osteoporosis with bisphosphonates. Clin IntervAging. 2006. 1: 415-23.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ridley A.J., Hall A. The small GTP-binding protein who regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992. 70:389-99.</mixed-citation><mixed-citation xml:lang="en">Ridley A.J., Hall A. The small GTP-binding protein who regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992. 70:389-99.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Russel RG. Determination of structure function relationships among bisphosphonates. Bone. 2007.40(suppk2):S21-25.</mixed-citation><mixed-citation xml:lang="en">Russel RG. Determination of structure function relationships among bisphosphonates. Bone. 2007.40(suppk2):S21-25.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Rizzoli R., Greenspan S.L., Bone G 3rd, et al. Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis. J Bone Miner Res. 2002. 17:1988-96.</mixed-citation><mixed-citation xml:lang="en">Rizzoli R., Greenspan S.L., Bone G 3rd, et al. Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis. J Bone Miner Res. 2002. 17:1988-96.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon D.H., Avom J., Katz J.N., et al. Compliance with osteoporosis medications. Arch Intern Med. 2005. 165(20): 2414-2419.</mixed-citation><mixed-citation xml:lang="en">Solomon D.H., Avom J., Katz J.N., et al. Compliance with osteoporosis medications. Arch Intern Med. 2005. 165(20): 2414-2419.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Siris E.S., Harris S.T., Rosen C.L., et al. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertabral fractures from 2US claims databases. Mayo Clinic Proc. 2006. 81:1013-22.</mixed-citation><mixed-citation xml:lang="en">Siris E.S., Harris S.T., Rosen C.L., et al. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertabral fractures from 2US claims databases. Mayo Clinic Proc. 2006. 81:1013-22.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Simon. J.A., Lewiecki E.M., Smith M.E., et al. Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: multicenter, randomized, open-label, crossover study. Clin Ther. 2002. 24(11): 1871-86.</mixed-citation><mixed-citation xml:lang="en">Simon. J.A., Lewiecki E.M., Smith M.E., et al. Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: multicenter, randomized, open-label, crossover study. Clin Ther. 2002. 24(11): 1871-86.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Тosteson A.N., Melton L.J.3rd, Dawson-Hughes B. et al. Cost-effective osteoporosis treatment thresholds: the United States perspective. Osteoporos Int 19(4); 437-447,</mixed-citation><mixed-citation xml:lang="en">Тosteson A.N., Melton L.J.3rd, Dawson-Hughes B. et al. Cost-effective osteoporosis treatment thresholds: the United States perspective. Osteoporos Int 19(4); 437-447,</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
