References

porozendo

Остеопороз и остеопатии

Osteoporosis and Bone Diseases

2072-26802311-0716

Endocrinology Research Centre

10.14341/osteo2012115-22

porozendo-4207

Research Article

Статьи

Articles

ОСТЕОПОРОЗ: КЛЕТОЧНО-МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ РАЗВИТИЯ И МОЛЕКУЛЫ-МИШЕНИ ДЛЯ ПОИСКА НОВЫХ СРЕДСТВ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ

OSTEOPOROSIS: CELLULAR AND MOLECULAR MECHANISMS OF DEVELOPMENT AND TARGET MOLECULES IN SEARCH FOR NEW TREATMENTS OF THE DISEASE

Sagalovski

Department of the Orthopoedic

sagalovsky@median-kliniken.de

2012

15042012

151

№1 (2012)

1522

2012

Sagalovski S.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.osteo-endojournals.ru/jour/article/view/4207

В обзоре литературы отражены современные представления о клеточно-молекулярном механизме развития остеопороза. Отражена значимость цитокиновой RANKL-RANK-OPG системы и Wnt/β-катенин сигнального пути в развитии процесса остеобласто- и остеокластогенеза Отмечена ключевая роль в процессе остеогенеза ряда молекул сигнальных клеточных систем и их антагонистов, представляющих интерес как молекулы-мишени для поиска новых лекрственных средств лечения остеопороза.

In a review of the literature reflects the modern understanding of the cellular-molecular mechanism development of osteoporosis. Reflects the importance of cytokine RANKL-RANK-OPG sistem and Wnt/β-catenin signaling pathway in the development process of osteoblasto- and osteoclastogenesis. Noting the key role in the process of bone formation a number of molecules of cell signaling pathway and their antagonists are of interest as a target molecule to search for new drugs treatment for osteoporosis.

остеопорозRANKL-RANK-OPG системаWnt/β-катенин сигнальный путьмолекулы-мишени

osteoporosisRANKL-RANK-OPG sistemWnt/β-catenin signaling pathwaytarget molecules

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The authors declare that there are no conflicts of interest present.