porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2013222-30porozendo-8855Research ArticleСтатьиArticlesРАЦИОНАЛЬНЫЙ ВЫБОР ФАРМАКОТЕРАПИИ ПОСТМЕНОПАУЗАЛЬНОГО ОСТЕОПОРОЗА.ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ БОНВИВЫ: ОБЗОР ЗА ВОСЕМЬ ЛЕТ ПРИМЕНЕНИЯRATsIONAL'NYY VYBOR FARMAKOTERAPII POSTMENOPAUZAL'NOGO OSTEOPOROZA.EFFEKTIVNOST' I BEZOPASNOST' BONVIVY: OBZOR ZA VOSEM' LET PRIMENENIYaБЕЛАЯЖ ЕBELAYaZh E-РОЖИНСКАЯЛ ЯROZhINSKAYaL Ya-ФГБУ Эндокринологический научный центр МЗ РФ201315122013162№2 (2013)2230Copyright © БЕЛАЯ Ж.Е., РОЖИНСКАЯ Л.Я., 20132013БЕЛАЯ Ж.Е., РОЖИНСКАЯ Л.Я.BELAYa Z.E., ROZhINSKAYa L.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/8855

Настоящий обзор литературы в основном посвящен анализу накопленных данных по эффективности, переносимости и безопасности ибандроната (Бонвива), полученных из рандомизированных контролируемых исследований, метаанализов, наблюдательных исследований, систематических обзоров и клинических наблюдений. отдельное внимание уделяется суррогатным критериям эффективности лечения, как используемым в рутинной клинической практике, так и новым высокотехнологичным методам, позволяющим оценить различные параметры костной прочности, в исследовательских центрах. Помимо зарегистрированного показания - постменопаузальный остеопороз, обзор затрагивает результаты исследовательских работ по применению ибандроната для профилактики постменопаузального остеопороза, лечения остеопороза у мужчин, лечения и профилактики глюкокортикоидного остеопороза, и других форм вторичного остеопороза, в частности, у пациентов после пересадки внутренних органов. В статье детально обсуждаются актуальные вопросы безопасности фармакологической терапии остеопороза.

In this critical review, we have summarized the specific evidence on ibandronic acid (Bonviva) efficacy, tolerability, feasibility and safety acquired from randomized controlled clinical trials, meta-analyses, bridging trials, long-term extension studies, observational studies and clinical experience. We have paid special attention to reviewing the surrogate endpoints, which are routinely used in clinical practice to estimate the treatment efficacy as well as those high technology methods that are currently used in research centers to predict anti-fracture efficacy. Although the only registered indication for Bonviva in Russia is for postmenopausal osteoporosis, we have reviewed the available clinical trials on the efficacy of ibandronic acid to prevent postmenopausal osteoporosis, to treat low bone mass in males, to treat and prevent glucocorticoid induced osteoporosis and other types of secondary osteoporosis and, in particular, in patients after organ transplantation. In addition to this, we have extensively discussed the currently available data on the safety of pharmacologic treatment for osteoporosis.

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The authors declare that there are no conflicts of interest present.