porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2013320-27porozendo-8864Research ArticleСтатьиArticlesФАКТОР РОСТА ФИБРОБЛАСТОВ 23 И БЕЛОК KLOTHO В ПАТОГЕНЕЗЕ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗАFIBROBLAST GROWTH FACTOR 23 AND KLOTHO PROTEIN IN THE PATHOGENESIS OF SECONDARY HYPERPARATHYROIDISMИльинА ВIlinA V

зав. лабораторией клинической биохимии

alexilin2005@yandex.ruАрбузоваМ ИArbuzovaM I

к.м.н., в.н.с. лаборатории клинической биохимии

-ФГБУ Эндокринологический научный центр Минздрава России201315122013163№3 (2013)2027Copyright © Ильин А.В., Арбузова М.И., 20132013Ильин А.В., Арбузова М.И.Ilin A.V., Arbuzova M.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/8864

Одними из основных проблем у пациентов с хроническим заболеванием почек (ХБП) являются нарушения кальций-фосфорного обмена, особенно при хроническом гемодиализе. Кроме классической эндокринной оси паращитовидные железы-почки, в последние годы было установлено существование новой эндокринологической оси кости-почки, что позволяет дать лучшее объяснение особенностям метаболизма кальция и фосфора, патофизиологии вторичного гиперпаратиреоза при ХБП. FGF23 является циркулирующим фактором, синтезирующимся остеоцитами, который ингибирует почечную реабсорбцию фосфатов и активность 1-альфагидроксилазы. Антивозрастный белок Klotho является мощным ко-фактором FGF23. В данном обзоре представлены особенности взаимодействия этих элементов новой оси в норме и при вторичном гиперпаратиреозе

One of the main problems in patients with chronic kidney disease (CKD) is a disturbance of calcium-phosphorus metabolism, especially in chronic hemodialysis. Besides classical endocrine axis parathyroid-kidney, in recent years was established the existence of a new endocrine axis the bone-kidney, which gives a better explanation of the calcium and phosphorus metabolism abnormalities, pathophysiology of secondary hyperparathyroidism in CKD. FGF23 is a circulating factor synthesized in osteocytes. It inhibits renal phosphate reabsorption and activity of 1-alphahydroxylase. Anti-aging Klotho protein is a potent co-factor of FGF23. This review presents the mechanisms of the interaction of these elements of the newly discovered axis in normal settings and secondary hyperparathyroidism.

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The authors declare that there are no conflicts of interest present.