porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2015215-19porozendo-8910Research ArticleСтатьиArticles«МУЛЬТИФАКТОРНОСТЬ ЭТИОПАТОГЕНЕЗА ОСТЕОПОРОЗА И РОЛЬ ГЕНОВ КАНОНИЧЕСКОГО WNT- СИГНАЛЬНОГО ПУТИ»MULTIFACTORIAL PATHOGENESIS OF OSTEOPOROSIS AND THE ROLE OF GENES OF CANONICAL WNT-SIGNALING PATHWAYМайлянЭ АMailyanE A

Кафедра клинической иммунологии, аллергологии и эндокринологии

mea095@yandex.ruДонецкий национальный медицинской университет им. М. Горького201515122015182№2 (2015)1519Copyright © Майлян Э.А., 20152015Майлян Э.А.Mailyan E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/8910

В настоящее время мультифакторность остеопороза не вызывает сомнений. наряду с этим следует отметить, что до 90% случаев заболевания генетически детерминировано. В 1990-х годах был установлен ряд генов-кандидатов, мутации в которых влияют на риск развития остеопороза. К ним были отнесены гены VDR, ESR1, ESR2, COLIA1, PTH, CT, CTR, BGP, AR, GCCR, TGFB1, IL-6, IGF1, IL-1ra, OPG и др. новые технологии генетического анализа (GWAS и др.) позволили существенно расширить наши представления о генной составляющей остеопороза и выделить новую патогенетическую группу генов-кандидатов - гены канонического Wnt-сигнального пути (CTNNB1, SOST, FOXC2, FOXL1, LRP4, LRP5, WNT1, WNT3, WNT16, DKK1, AXIN1, JAG1 и др.). чрезвычайная важность канонического WNT-сигнального пути и вышеуказанных генов в формировании скелета и его прочности свидетельствует о необходимости проведения дальнейших научных изысканий и открывает перспективы для совершенствования прогноза, диагностики и лечения остеопороза.

Nowadays, multifactorial nature of osteoporosis does not raise any doubts. Besides, it should be noted that about 90% disease cases are determined genetically. In 1990-s a number of candidate genes mutations were established which increase the risk of osteoporosis development. VDR, ESR1, ESR2, COLIA1, PTH, CT, CTR, BGP, AR, GCCR, TGFB1, IL-6, IGF1, IL-1ra, OPG were considered to be this kind of genes. New genetic analysis technologies (GWAS, etc.) gave the opportunity to expand our conception about multi genomic pathogenesis of osteoporosis and to point out a new group of genes candidate - a canonical Wnt-signaling pathway genes (CTNNB1, SOST, FOXC2, FOXL1, LRP4, LRP5, WNT1, WNT3, WNT16, DKK1, AXIN1, JAG1, etc.). Extreme importance of canonical Wnt-signaling pathway and genes given above in skeleton formation and its strength necessitate the need for further scientific research and opens perspective to improve osteoporosis diagnostics, treatment and prognosis.

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The authors declare that there are no conflicts of interest present.