porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2016128-34porozendo-8943Research ArticleСтатьиArticlesРОЛЬ МИОКИНОВ В МЕЖТКАНЕВОМ ВЗАИМОДЕЙСТВИИ И РЕГУЛЯЦИИ ОБМЕНА ВЕЩЕСТВ: ОБЗОР ЛИТЕРАТУРЫTHE ROLE OF MYOKINES INTERSTITIAL INTERACTION AND REGULATION OF METABOLISM: A REVIEW OF LITERATUREЦориевТимур ТамерлановичTsorievT T

аспирант отделения нейроэндокринологии и остеопатий

-БелаяЖанна ЕвгеньевнаWhiteZh E

заведующая отделением нейроэндокринологии и остеопатий - д.м.н

-РожинскаяЛюдмила ЯковлевнаRozhinskayaL Ya

главный научный сотрудник отделения нейроэндокринологии и остеопатий, д.м.н., профессор

-ФГБУ «Эндокринологический научный центр» Минздрава России201615122016191№1 (2016)2834Copyright © Цориев Т.Т., Белая Ж.Е., Рожинская Л.Я., 20162016Цориев Т.Т., Белая Ж.Е., Рожинская Л.Я.Tsoriev T.T., White Z.E., Rozhinskaya L.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/8943

В скелетных мышцах при физической нагрузке вырабатываются гормонально активные вещества - миокины, действующие как паракринно (в самих мышцах), так и по принципу эндокринной регуляции (в жировой ткани, печени, стенках сосудов, эпителиальных покровах и т.д.). Они оказывают разнообразные эффекты на ткани-мишени, как правило, регулируя метаболические процессы (углеводный и липидный обмен, рост и деление клеток нервной ткани и эндотелия сосудов и пр.). Изучение миокинов представляет большой интерес для специалистов разных областей медицины, особенно эндокринологов, ввиду вовлеченности миокинов в патогенез абдоминального и висцерального ожирения, сахарного диабета 2 типа, сердечно-сосудистых заболеваний - компонентов метаболического синдрома. Для врача-клинициста наиболее важна возможность использования в перспективе сигнальных путей миокинов для диагностики и лечения вышеуказанных заболеваний, а также некоторых других широко распространенных патологий.

Myokines are hormone-like acting molecules produced in skeletal muscles during and immediately after exercise. They affect both paracrine (inside the muscles themselves) and endocrine manner (in adipose tissue, liver, endothelium, skin, mucosa etc.) implementing different effects on target tissues, mainly through regulation of metabolic processes (such as glucose and lipid metabolism, growth and division of neurons and endothelial cells and others). The examination of myokines is of great interest for researchers of different medicine departments, particularly for endocrinologists, because of myokines’ involvement in pathogenesis of abdominal and visceral obesity, diabetes mellitus type 2 and cardiovascular diseases that are all the components of metabolic syndrome. The most important issue for clinicians is a possibility of future therapeutic implication of the myokine’s signal pathways in treatment of widespread metabolic disorders.

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The authors declare that there are no conflicts of interest present.