porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2017390-101porozendo-9373Research ArticleНаучный обзорReviewНеклассические эффекты витамина DNon-classical effects of vitamin Dhttps://orcid.org/0000-0001-6539-466XПигароваЕкатерина АлександровнаPigarovaEkaterina A.

к.м.н., в.н.с. отделения нейроэндокринологии и остеопатий

M.D., PhD

kpigarova@gmail.comhttps://orcid.org/0000-0002-7634-5457ПетрушкинаАлександра АлександровнаPetrushkinaAlexandra A.

клинический ординатор

MD

a.petrushkina@yandex.ru<p>ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России</p>Россия<p>Endocrinology Research Centre</p>Russian Federation20172404201820390101Copyright &#x00A9; Пигарова Е.А., Петрушкина А.А., 20172017Пигарова Е.А., Петрушкина А.А.Pigarova E.A., Petrushkina A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/9373

Интерес к роли витамина D в организме неуклонно растет со времени его открытия, и всё больше данных свидетельствует не только о необходимости витамина D для нормального развития и поддержания здоровья костной ткани, но и о его вкладе в адекватное функционирование других тканей организма. В связи с этим понимание особенностей метаболизма и физиологической роли витамина D в отдельных тканях представляется важным в связи с возможным вкладом в развитие патологических состояний. Особый интерес представляют интракринные регуляторные системы, связанные с широкой тканевой экспрессией ферментов метаболизма витамина D, а также способы поступления витамина D в клетку и активируемые при этом сигнальные пути. Связь местных эффектов с уровнем витамина D в крови выявляется в экспериментах на животных моделях и в клинических исследованиях; определение значений уровня витамина D, опосредующих его внекостные эффекты, может быть использовано для разработки соответствующих рекомендаций по коррекции уровня витамина D. В данном обзоре обсуждается опосредованное особенностями метаболизма влияние витамина D на иммунную функцию, а также связь витамина D с кожей, нервной системой, сердечно-сосудистой системой, ожирением и сахарным диабетом, онкологическими заболеваниями, репродуктивной функцией, предотвращением падений и улучшением качества жизни.

Since the discovery of vitamin D, interest in role of vitamin D in human body is consistently growing, and there is increasing evidence that vitamin D is not only essential to bone health but may also be involved in physiology of many other tissues. Thus understanding of its aspects in particular tissues appears to be important because of possible contribution to pathophysiologic processes. Intracrine regulatory systems associated with widely expressed vitamin D metabolizing enzymes, ways of cellular intake and signal pathways involved are of particular interest. Association of local effects with vitamin D level in blood is under investigation on animal models as well as in clinical studies; values of vitamin D level that mediate extraskeletal effects should be determined. In this review, we discuss impact of vitamin D on immune function and its association with skin, nervous system, cardiovascular system, obesity and diabetes mellitus, cancer, reproductive function, prevention of falls and quality of life improvement.

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The authors declare that there are no conflicts of interest present.