porozendoОстеопороз и остеопатииOsteoporosis and Bone Diseases2072-26802311-0716Endocrinology Research Centre10.14341/osteo2013129-33porozendo-8846Research ArticleСтатьиArticlesСОВРЕМЕННЫЙ ВЗГЛЯД НА ЭФФЕКТИВНОСТЬ ТЕРАПИИ ПОСТМЕНОПАУЗАЛЬНОГО ОСТЕОПОРОЗА. ИННОВАЦИОННЫЕ ПРЕПАРАТЫ ТАРГЕТНОЙ ТЕРАПИИMODERN VIEW ON THE EFFECTIVENESS OF THERAPY FOR POSTMENOPAUSAL OSTEOPOROSIS. INNOVATIVE DRUGS OF TARGETED ACTIONМокрышеваН ГMokryshevaN G

д.м.н., в.н.с. отделения нейроэндокринологии и остеопатий

nm70@mail.ruРожинскаяЛ ЯRozhinskayaL Ya

д.м.н., проф., Зав. отделения нейроэндокринологии и остеопатий

-ФГБУ ЭНЦ МЗ РФ201315122013161№1 (2013)2933Copyright © Мокрышева Н.Г., Рожинская Л.Я., 20132013Мокрышева Н.Г., Рожинская Л.Я.Mokrysheva N.G., Rozhinskaya L.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.osteo-endojournals.ru/jour/article/view/8846

Постепенное увеличение продолжительности жизни человека, стремление к улучшению ее качества требует улучшения результатов профилактики и лечения остеопороза. Основную часть лиц, подверженных ОП, составляют женщины в менопаузе. Разносторонний подход к проблеме восстановления баланса костного метаболизма привел к внедрению в практику препаратов с различными механизмами действия. В последнее время крайне важным аспектом является повышение приверженности к лечению пациентов, получающих многолетнее лечение остеопороза. Инновационным шагом является внедрение в практику применения нового препарата моноклонального человеческого антитела к лиганду RANK деносумаб. В обзоре представлены результаты сравнительных многоцентровых слепых рандомизированных исследований эффективности деносумаба и пероральных бисфосфонатов. Показано более выраженное достоверно влияние деносумаба (подкожно 60 мг 1 раз в 6 мес.) на прирост МПК во всех отделах скелета (как богатых трабекулярной, так и кортикальной костной тканью), значимое снижение риска переломов при хорошей переносимости лечения.

остеопорозпереломытрадиционная и таргетная терапия остеопорозаденосумаб

СОВРЕМЕННЫЙ ВЗГЛЯД НА ЭФФЕКТИВНОСТЬ ТЕРАПИИ ПОСТМЕНОПАУЗАЛЬНОГО ОСТЕОПОРОЗА. ИННОВАЦИОННЫЕ ПРЕПАРАТЫ ТАРГЕТНОЙ ТЕРАПИИ

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The authors declare that there are no conflicts of interest present.