EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza
Abstract
The aim of this study was to assess the effectiveness of the combined treatment with calcium and middle (400 mg daily) or high doses (800 mg daily) of vitamin D for prevention of osteoporosis in postmenopausal women with osteopenia in spine. Thirty patients, 45-70 years old, were divided into 3 equal groups: the women in the group 1 were treated with vitamin D3 400 IU. and calcium 1000 mg daily; the women in the group 2 received vitamin D3 800 IU and calcium 1000 mg daily; the patients from the group 3 did not receive any supplementation - the control 1 group.
A significant increase in BMD was found at lumbar spine (+1.9 % after 6 months, p<0.05) and trochanter (+4.6% after 6 months and +5.5% after 12 months, p<0.01) in the group 1. BMD did not significantly change in all regions of the skeleton in the group 2. However, there was a significant decrease vs. baseline in BMD at lumbar spine (p<0.05), Ward's triangle (p<0.05), trohanter (p<0.05) and total femur (p<0.001) in control group. We found a significant decrease of PTH, serum phosphorus and alkaline phosphatase in both treated groups, and there was a significant increase of PTH, alkaline phosphatase and osteocalcin and a decrease in serum calcium and daily calcium excretion in the control group.
These results demonstrate that combine therapy with calcium and middle or high doses of vitamin D is effective for the prevention of postmenopausal osteoporosis. Moreover, the consumption of the higher doses of vitamin D (800IU) increases BMD at spine and femur in postmenopausal women with osteopenia.
A significant increase in BMD was found at lumbar spine (+1.9 % after 6 months, p<0.05) and trochanter (+4.6% after 6 months and +5.5% after 12 months, p<0.01) in the group 1. BMD did not significantly change in all regions of the skeleton in the group 2. However, there was a significant decrease vs. baseline in BMD at lumbar spine (p<0.05), Ward's triangle (p<0.05), trohanter (p<0.05) and total femur (p<0.001) in control group. We found a significant decrease of PTH, serum phosphorus and alkaline phosphatase in both treated groups, and there was a significant increase of PTH, alkaline phosphatase and osteocalcin and a decrease in serum calcium and daily calcium excretion in the control group.
These results demonstrate that combine therapy with calcium and middle or high doses of vitamin D is effective for the prevention of postmenopausal osteoporosis. Moreover, the consumption of the higher doses of vitamin D (800IU) increases BMD at spine and femur in postmenopausal women with osteopenia.
About the Authors
A V DREVAL'L A MARChENKOVA
I V KRYuKOVA
R S TIShENINA
N V BALAShOVA
L M PORTNOY
N M MYLOV
M P RUBIN
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Review
For citations:
DREVAL' A.V., MARChENKOVA L.A., KRYuKOVA I.V., TIShENINA R.S., BALAShOVA N.V., PORTNOY L.M., MYLOV N.M., RUBIN M.P. EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza. Osteoporosis and Bone Diseases. 2007;10(1):20-24. (In Russ.)
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