Vliyanie narusheniya kostnogo metabolizma na sostoyanie tkaney parodonta u muzhchin reproduktivnogo vozrasta s sakharnym diabetom 1 tina i puti korrektsii
https://doi.org/10.14341/osteo2006314-22
Abstract
The aims of this study were to investigate the influence of alterations in bone metabolism and in hormonal and biochemical parameters on periodontium tissue as well as to estimate the optimal algorithm of investigation and treatment in men with diabetes mellitus type 1.
During the first stage (12 months) the comparative analysis of conditions of pariodontium tissue was conducted in 60 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group. During the second stage (12 months) the markers of bone metabolism and the conditions of paradontium tissue were studied in 26 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group.
The marker of bone resorption (CTX) was significantly lower (372,7 pkg/ml versus 473,0 pkg/ml; p= 0,006) and the marker of bone formation (OK) was significantly higher (27,6 ng/ml compared to 21,42 ng/ml; p< 0,005) in the group of patients who received ALPHA D3-TEVA (alfacalcidol 0,75mkg/day) and 2 tab CALCEMIN ADVANCE (calcium 1000 mg, cholecalciferol 400 UI) in comparison with the control group.
Conclusion: the treatment with Calcium and Vitamin D is effective for prevention of bone resorbtion, particularly in jaws.
During the first stage (12 months) the comparative analysis of conditions of pariodontium tissue was conducted in 60 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group. During the second stage (12 months) the markers of bone metabolism and the conditions of paradontium tissue were studied in 26 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group.
The marker of bone resorption (CTX) was significantly lower (372,7 pkg/ml versus 473,0 pkg/ml; p= 0,006) and the marker of bone formation (OK) was significantly higher (27,6 ng/ml compared to 21,42 ng/ml; p< 0,005) in the group of patients who received ALPHA D3-TEVA (alfacalcidol 0,75mkg/day) and 2 tab CALCEMIN ADVANCE (calcium 1000 mg, cholecalciferol 400 UI) in comparison with the control group.
Conclusion: the treatment with Calcium and Vitamin D is effective for prevention of bone resorbtion, particularly in jaws.
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For citations:
Grigoryan K.R., Grigoryan O.R., Nikonova T.V., Gorelysheva V.A., BARER G.M. Vliyanie narusheniya kostnogo metabolizma na sostoyanie tkaney parodonta u muzhchin reproduktivnogo vozrasta s sakharnym diabetom 1 tina i puti korrektsii. Osteoporosis and Bone Diseases. 2006;9(3):14-22. (In Russ.) https://doi.org/10.14341/osteo2006314-22
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