Preview

Остеопороз и остеопатии

Расширенный поиск

Возрастной гипогонадизм и остеопороз: патофизиология и возможности лечения

https://doi.org/10.14341/osteo2006336-41

Полный текст:

Об авторах

G Mskhalaya



S Kalinchenko



Список литературы

1. Клинические рекомендации по остеопорозу под ред. Л.И. Беневоленской и О.М. Лесняк. М.: ГЭОТАР-Медиа, 2005, 176 с.

2. Amin S., Felson D.T.: Osteoporosis in men. Rheum Dis Clin North Am 2001; 27: 19-47.

3. Amin S., Zhang Y., Sawin C.T., Evans S.R., Hannan M.T., Kiel D.P., Wilson P.W. & Felson D.T. Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study. Annals of Internal Medicine 2000 133 951-96

4. Anderson F.H., Francis R.M., Peaston R.T., Wastell H.J. Androgen supplementation in eugonadal men with osteoporosis: effects of six months' treatment on markers of bone formation and resorption. J Bone Miner Res. 1997 Mar;12 (3): 4721-8.

5. Bacon W.E., Smith G.S. & Baker S.P. Geographic variation in the occurrence of hip fractures among the elderly white US population. American Journal of Public Health 1989 79 1556-1558

6. Bellido T., Jilka R.L., Boyce B.F., Girasole G., Broxmeyer H., Dal rymple S.A., Murray R., Manolagas S.C. Regulation of interleukin-6, os teoclastogenesis, and bone mass by androgens. The role of the androgen receptor J Clin Invest. 1995 Jun;95 (6): 2886-95

7. Bilezikian J.P., Morishima A., Bell J., Grumbach M.M. Increased bone mass as a result of estrogen therapy in a man with aromatase defi ciency N Engl J Med. 1998 Aug 27;339 (9): 599-603

8. Bilezikian J.P. Osteoporosis in men. Journal of Clinical Endo crinology and Metabolism 1999 84 3431-3434.

9. Boonen S. & Vanderschueren D. Bone loss and osteoporotic fracture occurrence in aging men. In Textbook of Men's Health, pp 455-462. Eds В. Lunenfeld & L. Gooren. New York, NY: Parthenon Publishing Group, 2002

10. Burger H., de Laet C.E., van Daele P.L., Weel A.E., Witteman J.C., Hofman A. & Pols H.A. Risk factors for increased bone loss in an elderly population: the Rotterdam Study. American Journal of Epidemiology 1998 147 871-879

11. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S. & Simpson E.R. Effect of testosterone and estradiol in a man with aromatase deficiency. New England Journal of Medicine 1997 337 91-95

12. Chen J.R., Kousteni S., Bellido Т., Han L., DiGregorio G.B., Jilka R.L., Manogalas S.C. 2001 gender-independent induction of murine osteoclast apoptosis in vitro by either estrogens or non-aromatiz able androgens. J. Bone Miner res. 16 (Suppl 1): S159

13. Compston J. Local biosynthesis of sex steroids in bone. Journal of Clinical Endocrinology and Metabolism 2002 87 5398-5400 Consensus Development Conference. Diagnosis, prophylaxis, and treatment of osteoporosis. American Journal of Medicine 1993 94 646-650

14. Dargent-Molina P., Favier F., Grandjean H., et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 1996;348: 145-9.,

15. Donaldson L.J., Cook A. & Thomson R.G. Incidence of fractures in a geographically defined population. Journal of Epidemiology and Community Health 1990 44 241-245

16. Eriksen E.F., Colvard D.S., Berg N.J., Graham M.L., Mann K.G., Spelsberg T.C., Riggs B.L. Evidence of estrogen receptors in normal hu man osteoblast-like cells Science. 1988 Jul 1;241 (4861): 84-6

17. Falahati-Nini A., Riggs B.L., Atkinson E.J., O'Fallon W.M., Eastell R., Khosla S. Relative contributions of testosterone and estrogen in regu lating bone resorption and formation in normal elderly men J Clin Invest. 2000 Dec;106 (12): 1553-60

18. Faustini-Fustini M., Rochira V. & Carani С. Oestrogen defi ciency in men: where are we today? European Journal of Endocrinology 1999 140 111-129

19. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., Bremner W.J. & McKinlay J.B. Age trends in the level of serum testosterone and other hormones in middle aged men: longitudinal results from the Massachusetts Male Aging Study. Journal of Clinical Endocrinology and Metabolism 2002 87 589-598

20. Gooren L.J. & Toorians A.W. Significance of oestrogens in male (patho) physiology. Annales d'Endocrinologie 2003 64 126-135

21. Grumbach M.M. Estrogen, bone, growth and sex: a sea change in conventional wisdom J Pediatr Endocrinol Metab. 2000; 13 Suppl 6: 1439-55

22. Hannan M.T., Felson D.T., Anderson J.J.: Bone mineral density in elderly men and women: Results from the Framingham Osteoporosis study. J Bone Miner Res 1992; 7: 547-553

23. Harman S.M., Metter E.J., Tobin J.D., Pearson J. & Blackman M.R. Lon gitudinal effects of aging on serum total and free testosterone levels in healthy men. Journal of Clinical Endocrinology and Metabolism 2001 86 724-731

24. Hughes D.E., Dai A., Tiffee J.C., Li H.H., Mundy G.R., Boyce B.F. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF- beta Nat Med. 1996 Oct; 2 (10): 1132-6

25. Jackson J.A., Riggs M.W., Spiekerman A.M. Testosterone defi ciency as a risk factor for hip fractures in men: a case-control study Am J Med Sci. 1992 Jul;304 (1): 4-8.

26. Karlsson M.K. Skeletal effects of exercise in men. Calcif Tissue Int. 2001; 69: 196-9

27. Kasperk C.H., Wergedal J.E., Farley J.R., Linkhart Т.А., Turner R.T., Baylink D.J. Androgens directly stimulate proliferation of bone cells in vitro Endocrinology. 1989 Mar; 124 (3): 1576-8

28. Katznelson L., J.S. Finkelstein, D.A. Schoenfeld, D.I. Rosenthal, E.J. Anderson and A. Klibanski. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism 12.

29. Kenny A.M., Prestwood K.M., Marcello K.M. & Raisz L.G. Deter minants of bone density in healthy older men with low testosterone lev els. Journal of Gerontology Series A: Biological Sciences and Medical Sciences 2000 55 492-497

30. Khosla S., Melton L.J. 3rd. & Riggs B.L. Estrogens and bone health in men. Calcified Tissue International 2001 69 189-192.

31. Khosla S., Melton L.J. 3rd., Atkinson E.J. & O'Fallon W.M. Re lationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. Journal of Clinical Endocrinology and Metabolism 2001 86 3555-3561

32. Khosla S., Melton L.J. 3rd., Atkinson E.J., O'Fallon W.M., Klee G.G. & Riggs B.L. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bio available estrogen. Journal of Clinical Endocrinology and Metabolism 1998 83 2266-2274

33. Lombardi A., Ross P.D.: The assessment of bone mass in men. Calcif Tissue Int 2001; 69: 222-224.

34. Looker A.C., Orwoll E.S., Johnston C.C. Jr., Lindsay R.L., Wahner H.W., Dunn W.L., Calvo M.S., Harris Т.В. & Heyse S.P. Prevalence of low femoral bone density in older U.S. adults from NHANES III. Journal of Bone and Mineral Research 1997 12 1761-1768

35. Majeska R.J., Ryaby J.T., Einhorn TADirect modulation of osteoblastic activity with estrogen J Bone Joint Surg Am. 1994 May;76 (5): 713-21

36. Manolagas S.C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of oste oporosis Endocr Rev. 2000 Apr; 21 (2) : 115-37

37. Melton L.J. III, Chrischilles E.A., Cooper C., Lane A.W., Riggs B.L.: How many women have osteoporosis? J Bone Miner Res 1992;7: 1005-1010

38. Morales A., Lunenfeld B. Androgen replacement therapy in aging men with secondary hypogonadism. Draft recommendations for endorsement by ISSAM. Aging male 2001;4;151-62

39. Olszynski W.P., Davison S.K., Adachi J.D.: Osteoporosis in men: Epidemiology, diagnosis, prevention, and treatment. Clin Ther 2004; 26: 15-28.

40. O'Neill T.W., Felsenberg D., Varlow J., Cooper C., Kanis J.A., Simian A.J. The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res. 1996 Jul; ll(7): 1010-8.

41. Orwoll E.S. & Klein R.F. Osteoporosis in men. Endocrine Re views 1995 16 87-116

42. Orwoll E.S.: Osteoporosis in men. Endocrinol Metab Clin North Am 1998; 27: 349-367.

43. Oursler M.J., Pederson L., Fitzpatrick L., Riggs B.L., Spelsberg T. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells Proc Natl Acad Sci USA. 1994 Jun 7; 91 (12): 5227-31

44. Parfitt A.M. 2000 Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis. In:

45. Marcus R., Feldman D., Kelsey J., eds. Osteoporosis. 2nd ed. San Diego: Academic Press; 433-447

46. Pederson L., Kremer M., Judd J., Pascoe D.., Spelsberg T.C., Riggs B.L., Oursler M.J. Androgens regulate bone resorption activity of isolat- ed osteoclasts in vitro Proc Natl Acad Sci USA. 1999 Jan 19; 96 (2): 505-10.

47. Qu Q., Perala-Heape M., Kapanen A., Dahllund J., Salo J., Vaananen H.K., Harkonen P. Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture Bone. 1998 Mar, 22 (3): 201-9

48. Riggs B.L., Khosla S. & Melton L.J. 3rd. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. Journal of Bone and Mineral Research 1998 13 763-773

49. Rochira V., Balestrieri A., Faustini-Fustini M. & Carani C. Role of estrogen on bone in the human male: insights from the natural models of congenital estrogen deficiency. Molecular and Cellular Endocrinology 2001 178 215-220

50. Rochira V., Balestrieri A., Madeo B., Zirilli L., Granata A.R.M., Carani С. Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho) physiology. European Journal of Endocrinol ogy, 2006, Vol 154, Issue 2, 175-185

51. Sanders K.M., Seeman E., Ugoni A.M., Pasco J.A., Martin T.J., Skoric B., Nicholson G.C. & Kotowicz M.A. Age- and gender-specific rate of fractures in Australia: a population-based study. Osteoporosis Interna tional 1999 10 240-247

52. Scopacasa F., Horowitz M., Wishart J.M., Morris H.A., Chatterton B.E. & Need A.G. The relation between bone density, free androgen index, and estradiol in men 60 to 70 years old. Bone 2000 27 145-149

53. Seeman E. Pathogenesis of bone fragility in women and men. Lancet 2002 359 1841-1850.

54. Sernbo I., Johnell O.: Consequences of a hip fracture: A prospec tive study over 1 year. Osteoporos Int 1993; 3: 148-153.

55. Slemenda C.W., Longcope C., Zhou L., Hui S.L., Peacock M. & Johnston C.C. Sex steroids and bone mass in older men. Positive asso ciations with serum estrogens and negative associations with androgens. Journal of Clinical Investigation 1997 100 1755-1759

56. Smith E.P., Boyd J., Frank G.R., Takahashi H., Cohen R.M., Specker B., Williams T.C., Lubahn D.B., Koraeh K.S. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med. 1994 Oct 20; 331 (16): 1056-61

57. Turner R.T., Colvard D.S., Spelsberg T.C. Estrogen inhibition of perio steal bone formation in rat long bones: down-regulation of gene expression for bone matrix proteins Endocrinology. 1990 Sep;127(3): 1346-51

58. Vanderschueren D., Vandenput L., Boonen S., Lindberg M.K., Bouillon R. & Ohlsson С. Androgens and bone. Endocrine Reviews 2004 25 389-425

59. Vermeulen A., Kaufman J.M., Goemaere S. & van Pottelberg I. Estradiol in elderly men. Aging Male 2002 5 98-102.

60. Vermeulen A. some reflections on the endocrinology of the ag ing male. The Aging, ale. 1998; 16: 163-8.

61. Wakley G.K., Schutte H.D. Jr., Harmon K.S., Turner R.T. Androgen treatment prevents loss of cancellous bone in the orchidectomized rat J Bone Miner Res. 1991 Apr; 6 (4): 325-30

62. Windahl S.H., Vidal O., Andersson G., Gustafsson J.A., Ohlsson С. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta (-/-) mice J Clin Invest. 1999 Oct; 104 (7): 895-901

63. Wright J. Vonda Osteoporosis in Men J Am Acad Orthop Surg, Vol 14, No 6, June 2006, 347-353

64. Ferrando Arny A., Melinda Sheffield-Moore, Catherine W. Yeckel, Charles Gilkison, Jie Jiang, Alison Achacosa, Steven A. Lieber man, Kevin Tipton, Robert R. Wolfe, and Randall J. Urban Testosterone administration to older men improves muscle function: molecular and physiological mechanisms Am J Physiol Endocrinol Metab, Mar 2002; 282: 601-607

65. National Osteoporosis Foundation: America's Bone Health: The State of Osteoporosis and Low Bone Mass in Our Nation. Washing ton, DC: National Osteoporosis Foundation, 2002

66. Orwoll Eric, Mark Ettinger, Stuart Weiss, Paul Miller, David Kendler, John Graham, Silvano Adami, Kurt Weber, Roman Lorenc, Peter Pietschmann, Kristel Vandormael, and Antonio Lombardi Alen dronate for the Treatment of Osteoporosis in Men N. Engl. J. Med., Aug 2000; 343: 604-610

67. Wittert Gary A., Ian M. Chapman, Matthew T. Haren, Shylie Mackintosh, Penelope Coates, and John E. Morley Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status J. Gerontol. A Biol. Sci. Med. Sci., Jul 2003; 58: 618 -625.).

68. World Health Organization Adherence to long-term therapies: evidence for action. 2003. WHO/MNC/03/01

69. Orwoll Eric, Mark Ettinger, Stuart Weiss, Paul Miller, David Kendler, John Graham, Silvano Adami, Kurt Weber, Roman Lorenc, Peter Pietschmann, Kristel Vandormael, and Antonio Lombardi Alen dronate for the Treatment of Osteoporosis in Men N. Engl. J. Med., Aug 2000; 343: 604-610

70. Wittert Gary A., Ian M. Chapman, Matthew T. Haren, Shylie Mackintosh, Penelope Coates, and John E. Morley Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status J. Gerontol. A Biol. Sci. Med. Sci., Jul 2003; 58: 618 -625.).


Рецензия

Для цитирования:


., . Возрастной гипогонадизм и остеопороз: патофизиология и возможности лечения. Остеопороз и остеопатии. 2006;9(3):36-41. https://doi.org/10.14341/osteo2006336-41

For citation:


Mskhalaya G.Z., Kalinchenko S.Yu. Vozrastnoy gipogonadizm i osteoporoz: patofiziologiya i vozmozhnosti lecheniya. Osteoporosis and Bone Diseases. 2006;9(3):36-41. (In Russ.) https://doi.org/10.14341/osteo2006336-41

Просмотров: 348


ISSN 2072-2680 (Print)
ISSN 2311-0716 (Online)