Interrelation of bone mineral density with kneeosteoarthrosis
https://doi.org/10.14341/osteo2011119-20
Abstract
Association of bone mineral density (BMD) of axial skeleton with age of the disease onset as well as with clinical traits and instrumental investigation findings has been studied in osteoarthritic patients. 116 females with primary knee OA, 74 ofwhich exhibited normal or increased
BMD at lumbar spine and 42, with osteoporosis were included in the study. Knee joint pain was measured using visual analog scale (VAS). All the patients were subjected to X-ray analysis of their knee joints at two sites (OA stage was
determined according to Kellgren-Lawrence scale), densitometry at lumbar spine and proximal femur using QDR-4500W (Hologic), MRT, and ultrasonography of the knee joints.
We determined that the increasedBMD at lumbar spine was associated with early OA onset, more pronounced X-ray changes in the knee joints and higher frequency of varus deformation development in tibial bones.
BMD at lumbar spine and 42, with osteoporosis were included in the study. Knee joint pain was measured using visual analog scale (VAS). All the patients were subjected to X-ray analysis of their knee joints at two sites (OA stage was
determined according to Kellgren-Lawrence scale), densitometry at lumbar spine and proximal femur using QDR-4500W (Hologic), MRT, and ultrasonography of the knee joints.
We determined that the increasedBMD at lumbar spine was associated with early OA onset, more pronounced X-ray changes in the knee joints and higher frequency of varus deformation development in tibial bones.
About the Authors
E. M. ZaytsevaA. V. Smirnov
L. I. Alekseeva
E. M. Zaitseva
A. V. Smirnov
L. I. Alekseeva
References
1. Burger H., van Daele P.L.A., Odding E., et al. Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age; the Rotterdam study. Arthritis Rheum., 1996;39:81-6.
2. Dequeker J. Inverse relationship of interface between osteoporosis and osteoarthritis. J.Rheumatol., 1997;4:795-8.
3. Foss M.V.L., Byers P.D. Bone density, osteoarthritis of the hip, and fracture of the upper end of the femur. Ann.Rheum.Dis., 1972;31:259.
4. Hannan M.T., Anderson J.J., Zhang Y., et al. Bone mineral density and knee osteoarthritis in erderly men and woman. The Framingham Study. Arthritis Rheum., 1993;12:1671-80.
5. Hart D.J., Mootoosamy I., Doyle S.V., et al. The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann.Rhem.Dis., 1994;53:158-62.
6. Hochberg M.C., Lethbridge-Cejku M., Tobin J.D. Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage, 2004;12 Suppl A:S45-8.
7. Nevitt M.C., Zhang Y., Javaid M.K., et al. High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study. Ann. Rheum. Dis., 2010;69(1):163-8.
8. Sowers M., Lachance L., Jamadar D., et al. The association of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal woman. Arthritis Rheum., 1999;42:483-9.
9. Zhang Y., Hannan M.T., Chaisson C.E., et al. Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in woman: Framingham Study. J.Rheumatol., 2000;27(4):1032-7.
Review
For citations:
Zaytseva E.M., Smirnov A.V., Alekseeva L.I., Zaitseva E.M., Smirnov A.V., Alekseeva L.I. Interrelation of bone mineral density with kneeosteoarthrosis. Osteoporosis and Bone Diseases. 2011;14(1):19-20. (In Russ.) https://doi.org/10.14341/osteo2011119-20
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