MICROELEMENTS IN THE PREVENTION OF OSTEOPOROSIS: FOCUS ON SILICON
https://doi.org/10.14341/osteo2014236-40
Abstract
The present review of literature is focusing on the role of the trace element silicon in the process of remodeling of bone tissue and exploring the possibility of using the silicon-containing supplements in the complex prevention of osteoporosis. The experimental studies had proved the involvement of silicon in the development of connective tissue, formation and mineralization of bone tissue. A few clinical trials showed a positive effect of silicon supplements on the bone mass and markers of a bone metabolism. Because the potential biological role of silicon in osteogenesis was not completely studied the growing attention of the scientific medical community to this important nutrient will improve the understanding of its role and place in the formation of healthy bone tissue, and its use to prevent the development of osteoporosis.
References
1. Jugdaohsingh R. Silicon and bone health. J. Nutr. Health Aging. 2007; 11(2): 99-110.
2. Ребров В.Г., Громова О.А. Витамины, микро- и макроэлементы - М: ГЭОТАР-Медиа, 2008. 960с.
3. Price C.T., Koval K.J., Langford J.R. Silicon: A Review of Its Potential Role in the Prevention and Treatment of Postmenopausal Osteoporosis. Int. Endocrinol 2013; Volume 2013. Article ID 316783. P6.
4. Martin K.R. The chemistry of silica and its potential health benefits. Journal of Nutrition, Health and Aging. 2007; 11(2): 94-98.
5. Jugdaohsingh R., Calomme M.R., Robinson K., et al. Increased longitudinal growth in rats on a silicon-depleted diet. Bone. 2008; 43(3): 596-606.
6. Seaborn C.D., Nielsen F.H. Dietary silicon affects acid and alkaline phosphatase and 45calcium uptake in bone of rats. Journal of Trace Elements in Experimental Medicine. 1994; 7(1): 11-18.
7. Kayongo-Male H., Julson J.L. Effects of high levels of dietary silicon on bone development of growing rats and turkeys fed semi-purified diets. Biological Trace Element Research. 2008; 123(1-3): 191-201.
8. Kim M.H., Bae Y.J., Choi M.K., et al. Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption. Biological Trace Element Research.2009; 128(3): 239-247.
9. Jugdaohsingh R., Anderson S.H., Tucker K.L., et al. Dietary silicon intake and absorption. Am J Clin Nutr. 2002; 75: 887-893.
10. Reffitt D.M., Ogston N., Jugdaohsingh R., et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003; 32 (2): 127-135.
11. Sripanyakorn S., Jugdaohsingh R., Dissayabutr W., et al. The comparative absorption of silicon from different foods and food supplements. Br J Nutr. 2009; 102(6): 825-834.
12. Charnot A. Osteoporosis and osteomalyation at the African population. Prod. Pharm.1959; 3: 126.
13. Laane Henk-Maarten. Humans: beneficial or essenyial? - http://www.perma-guard.com.pl/uploads/files/de_for_humans.pdf
14. Скальный А.В., Рудаков И.А. Биоэлементы в медицине - М.: Оникс 21 век; Мир, 2004. 272с.
15. Кудрин Л.В., Скальный А.В., Жаворонков А.А. и др. Иммунофармакология микроэлементов - М.: КМК, 2000. 537с.
16. McNaughton S.A., Bolton-Smith C., Mishra G.D., et al. Dietary silicon intake in post-menopausal women. Br J Nutr. 2005; 94: 813-817.
17. Anasuya A., Bapurao S., Paranjape P.K. Fluoride and silicon intake in normal and endemic fluorotic areas. Journal of Trace Elements in Medicine and Biology. 1996; 10: 149-155.
18. Aguilar F., Dusemund B., Galtier P., et al. Scientific opinion: monomethylsilanetriol added for nutritional purposes to food supplements. European Food Safety Authority Journal. 2009; 950: 1-12.
19. Jugdaosingh R., Tucker K.L., Qiao N., et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham offspring cohort. J Bone Miner Res. 2004; 19(2): 297-307.
20. Price Ch.T., Langford J.R., Liporace F.A. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. The Open Orthopaedics Journal. 2012; 6: 143-149.
21. Pennington J.A.T. Silicon in foods and diets. Food Additives and Contaminants.1991; 8: 97-118.
22. Powell J.J., McNaughton S.A., Jugdaohsingh R., et al. A provisional database for the silicon content of foods in the United Kingdom. Brit. J Nutr. 2005; 94: 804-812.
23. Nielsen F.H. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. The FASEB Journal. 1991; 5: 2661-2667.
24. Carlisle E.M. Silicon: a possible factor in bone calcification. Science.1970; 167(3916): 279-280.
25. Miclau T., Bozic K.J., Tay B., et al. Bone injury, regeneration, and repair. / Orthopedic Basic Science: Foundations of ClInical Practice. T.A. Einhorn, R.J. O’Keefe, and J.A. Buckwalter, Eds., pp. 331-348, American Adacemy of Orthopedic Surgeons, Rosemont, Ill, USA, 2007.
26. Nielsen F.H., Sandstead H.H. Are nickel, vanadium, silicon, fluorine, and tin essential for man? A review. Am J Clin Nutr. 1974; 27(5): 515-20.
27. Ребров В.Г., Громова О.А. Витамины, микро- и макроэлементы - М.: ГЭОТАР-Медиа, 2008. 960с.
28. Schwarz K. A bound form of silicon in glycosaminoglycans and polyuronides. Proceedings of the National Academy of Sciences USA. 1973; 70: 1608-1612.
29. Booth S.L. Vitamin K and the Skeleton. Nutritional aspects of Osteoporosis. Edited by Burckhardt P., Dawson-Hughess B., Heaney R.P. Academic Press. 2001. 273-284.
30. Bügel S. Vitamin K and bone health in adult humans. In: Litwack G., editor. Vitamins and Hormones: Vitamin K. London: Elsevier; 2008. pp. 393-416.
31. National Academy of Sciences. A Report of the Panel on Micronutrients. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington DC: National Academy Press; 2001.
32. Macdonald H.M., Hardcastle A.E., Jugdaohsingh R., et al. Dietary silicon intake is associated with bone mineral density in premenopasual women and postmenopausal women taking HRT. Journal of Bone Mineral Research. 2005; 20: 393.
33. Eisinger J., Clairet D. Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study. Magnesium Research. 1993; 6(3): 247-249.
34. Schiano A., Eisinger F., Detolle P., et al. Silicium, tissu osseux et immunité Revue du Rhumatisme. 1979; 46: 483-486.
35. Spector T.D., Calomme M.R., Anderson S.H., et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebocontrolled trial. BMC Musculoskeletal Disorders. 2008; 9 (85) - http://www.biomedcentral.com/1471-2474/9/85
36. Spector T.D., Calomme M.R., Anderson S., et al. Effect of bone turnover and BMD of low dose oral silicon as an adjunct to calcium/vitamin D3 in a randomized placebo-controlled trial. Journal of Bone Mineral Research. 2005; 20: 172.
Review
For citations:
Skripnikova I.A., Gur’ev A.V. MICROELEMENTS IN THE PREVENTION OF OSTEOPOROSIS: FOCUS ON SILICON. Osteoporosis and Bone Diseases. 2014;17(2):36-40. (In Russ.) https://doi.org/10.14341/osteo2014236-40
Views:
16104
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
