Pharmacotherapy of cardiovascular comorbidities in osteoporotic postmenopausal women
https://doi.org/10.14341/osteo2017117-21
Abstract
Aim: to assess tolerability and efficacy of cardiovascular comorbidities pharmacotherapy in osteoporotic postmenopausal women.
Methods: cross-sectional study included 112 osteoporotic postmenopausal women aged from 49 to 85.
Results: 95 persons (84.8%) had indications for angiotensine-convertising enzyme inhibitors (ACEI) prescription. Cough was associated with significantly higher odds of coronary heart disease, congestive heart failure and a trend to multiple bone fractures. Valsartan was initiated in 32 coughing patients. Target blood pressure level was reached in 15 women. In 15 cases blood pressure levels decreased by 30% of baseline level.
Conclusion: efficacy of cardiovascular diseases in osteoporotic postmenopausal women treatment needs to be assessed in specially designed clinical trials.
About the Authors
Nadezhda V. IzmozherovaUral State Medical University
Russian Federation
MD, PhD, professor
Artem A. Popov
Ural State Medical University
Russian Federation
MD, PhD, professor
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Supplementary files
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1. Рисунок 1. Частота применения ингибиторов АПФ у женщин с постменопаузальным остеопорозом. | |
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2. Рисунок 2. Динамика достижения целевых цифр АД на фоне применения валсартана: Критерий МакНимара, p<0,001. | |
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3. Рисунок 3. Динамика функциональных классов хронической сердечной недостаточности: Критерий МакНимара, p<0,001. | |
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For citations:
Izmozherova N.V., Popov A.A. Pharmacotherapy of cardiovascular comorbidities in osteoporotic postmenopausal women. Osteoporosis and Bone Diseases. 2017;20(1):17-21. (In Russ.) https://doi.org/10.14341/osteo2017117-21
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