Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints.
Abstract
Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee II–III stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity.
This article is the PeReint of the original publication in Obesity and Metaboilism (2014) 11(4); pp. 41-47. doi: 10.14341/omet2014441-47
About the Authors
Inna Vladimirovna Solov'eva
Moscow State University of Medicine and Dentistry named after AI Evdokimov, Moscow
Russian Federation
Russian Federation
Assistant of the Endocrinology and Diabetology Department
Ekaterina Aleksandrovna Strebkova
Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Fellow Researcher
lyudmila Ivanovna Alekseeva
Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
MD, PhD, professor
Ashot Musaelovich Mkrtumyan
Moscow State University of Medicine and Dentistry named after AI Evdokimov, Moscow
Russian Federation
Russian Federation
MD.PhD, professor of endocrinology and diabetology department
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Review
For citations:
Solov'eva I.V., Strebkova E.A., Alekseeva l.I., Mkrtumyan A.M. Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints. Osteoporosis and Bone Diseases. 2017;20(4):11-18. (In Russ.)
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