PREVALENCE OF VITAMIN D DEFICIENCY IN PEOPLE OVER 50 YEARS OLD RESIDING IN REPUBLIC OF BASHKORTOSTAN IN PERIODS OF LOW INSOLATION
Abstract
Objectives. To study the vitamin D levels in the period of minimal sun exposure in individuals older than 50 years residing in the Republic of Bashkortostan. Materials and methods. In the period of low insolation (March) in 188 people (68 men and 120 women) aged over 50 years (mean age 66,1 ± 0,75 years) residing in the city (Ufa) and rural areas of the Republic of Bashkortostan we investigated the levels of 25 (OH) D and parathyroid hormone (PTH) by the indirect ELISA. Level of 25 (OH) D 25-50 nmol/l were considered as mild vitamin D deficiency; 12,5-25 nmol/l-as moderate deficiency, and levels below 12.5 nmol/l - as a severe vitamin D deficiency. Results. The average level of 25 (OH) D was 33,55 ± 1,28 nmol/l; in urban area 43,48 ± 1,59 nmol/l; in rural area 21,25 ± 1,06 nmol/l; 36,29±2,43 nmol/l in men; 32,28± 1,47 nmol/l in women. The levels of vitamin D in the urban population were twice as high as in rural areas. A statistically significant difference by gender in terms of the levels of vitamin D was not found. We saw normal levels of vitamin D only in 18 % of subjects (in the city- 30 %, in the rural areas - 2 %), 43 % of people had a mild vitamin D deficiency (in the city - 59 %, in rural areas - 24 %), 33 % - a moderate deficiency of vitamin D (in the city -11 %, in the rural areas - 60 %), and 6 % of the patients had a severe vitamin D deficiency (in the city - 0 %, in rural areas -14 %). Moderate to severe vitamin D deficiency in rural areas was significantly more prevalent (74 %) than in urban (11 %). Gender was not found to be a risk factor for the development of vitamin D deficit in people over 50 years. There was a negative correlation between vitamin D levels and patient age (r=-0,356, p <0,001) and between levels of vitamin D andPTH (r =-0,313, p <0.001).
About the Authors
R Z Nurlygayanovkandidat meditsinskikh nauk, chlen RAPO
E R Syrtlanova
doktor meditsinskikh nauk, glavnyy vrach
References
1. Meyer H.E., Henriksen C., Falch J.A., Pedersen J.L., Tvcrdal A. Risk factors for hip fracture in a high incidence area: a case-control study from Oslo, Norway // Osteoporos. Int. - 1995. - 5. - P. 239 - 246.
2. Cummings S.R., Browner W.S., Bauer D., et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group // N. Engl. J. Med. - 1998. - 339. - P. 733 - 738.
3. Lips P Vitamin D deficiency and osteoporosis: the role of vitamin D deficiency and treatment with vitamin D and analogues in the prevention of osteoporosis-related fractures // European J. of Clin. Investigation. - 1996. - 26. - P. 436 - 442.
4. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications // Endocrine Reviews. - 2001. - 22(4). - P. 477 - 501.
5. Масаси Кабаяси. Предотвращение возникновения карциномы толстого кишечника с помощью витамина D и кальция // Витамин-Vitamins. - 1988. - Т. 62. - № 29. - C. 533.
6. Walters M.R. Newly identified actions of the vitamin D endocrine system // Endocr. Rev. - 1992. - 13. - P. 719 - 764.
7. Zipitis C.S., Akobeng A.K. Vitamin D supplementation in early childhood and meta-analysis and risk of type I diabetes: a systematic review // Arch. Dis. Child. - 2008. - Vol. 93. - P. 512 - 517.
8. Pearce S.H.S., Cheetham T.D. Diagnosis and management of vitamin D deficiency // Br. Med. J. - 2010. -Vol. 340. - P. 142 - 147.
9. Christine N., Dao et al. Low Vitamin D among HIV-Infected Adults: Prevalence of and Risk Factors for Low Vitamin D Levels in a Cohort of HIV-Infected Adults and Comparison to Prevalence among Adults in the US General Population // Clin. Infect. Dis. - 2011. - 52(3). - P. 396 - 405.
10. Holick M.F. Vitamin D and the skin: Photobiology, physiology and therapeutic efficacy // Bone Miner. Res. - 1990. - Vol. 7. - Amsterdam: Elsevier - P. 313 - 366.
11. Parfitt F.V., Gallagher J.C., Heaney R.P., et al. Vitamin D and bone health in the elderly // Am. J. Clin. Nutr. - 1982. - 36. - P. 1014 - 1031.
12. McKenna M. Differences in vitamin D status between countries inyoung adults and elderly // Am. J. Med.- 1992. - 93. - P. 69 - 77.
13. Бахтиярова С.А., Лесняк О.М. Дефицит витамина D среди пожилых людей // Общая врачебная практика. - 2004. - № 1. - C. 26 - 32.
14. Торопцова Н.В. Эпидемиология, первичная профилактика и лечение постменопаузального остеопороза в условиях поликлиники: Дис.. д-ра мед. наук. - Москва. - 2007. - 225 с.
15. Витебская А.В., Смирнова Г.Е., Ильин А.В. Витамин Д и показатели кальций-фосфорного обмена у детей, проживающих в средней полосе России, в период максимальной инсоляции // Остеопороз и остеопатии. - 2010. - № 2. - С. 2 - 5.
16. Каронова Т.Л., Мамина И.А., Коноплянникова Е.В., Ктышева Н.С., Галкина О.В., Буданова М.В., Гринева Е.Н. Уровень витамина Д3 и паратиреоидного гормона у женщин пре- и перименопаузального возраста // Остеопороз и остеопатии. - 2010. - № 1. - Тезисы IV Российского конгресса по остеопорозу. - Санкт-Петербург, 26 - 29 сентября 2010 г. - C. 36.
17. Шилин Д.Е., Осипова Т.А., Костина Л.В., Адамян Л.В. Дефицит витамина D в Москве - межсезонный фактор риска остеопороза и падений «без пола и возраста» // Остеопороз и остеопатии. - 2010. - № 1. - Тезисы IV Российского конгресса по остеопорозу. - Санкт-Петербург, 26 - 29 сентября 2010 г. - C. 37.
18. Pun K.K., Wong F.N.W., Wang C. et al. Vitamin D status among patients with fractured neck of femur in Hong Kong. // Bone. - 1990. - 11. - C. 365 - 368.
19. Шилин Д.Е. Витамин-гормон D в клинике XXI века: плейотропные эффекты и лабораторная оценка (Лекция) // Клиническая лабораторная диагностика. - 2010. - № 12. - C.1 - 8.
20. Chapuy M.C., Arlot M.E., Duboeuf F. et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women // J. N. Engl. Med. - 1992. - 327. - P1637 - 1642.
21. Zhao X.H. Nutritional situation of Beijing residents // J. Trop. Med. Pub. Health. - 1992. - 23 (suppl. 3). - P. 65 - 68.
22. Khaw K.T., Scragg R., Murphy S. Single-dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial // Am. J. Clin. Nutr. - 1994. - 59. - P. 1040 - 1044.
23. Janssen H.C., Samson M.M., Verhaar H.J. Vitamin D deficiency, muscle function, and falls in elderly people // Am. J. Clin. Nutr. - 2002. - Vol. 75. - 4. - P. 611 - 615.
Review
For citations:
Nurlygayanov R.Z., Syrtlanova E.R. PREVALENCE OF VITAMIN D DEFICIENCY IN PEOPLE OVER 50 YEARS OLD RESIDING IN REPUBLIC OF BASHKORTOSTAN IN PERIODS OF LOW INSOLATION. Osteoporosis and Bone Diseases. 2012;15(3):7-9. (In Russ.)
Views:
422
Email this article 
