COMBINATION THERAPY IN THE TREATMENT OF OSTEOARTHRITIS. THE EFFECTIVENESS OF THERAFLEX
Abstract
Osteoarthritis (OA) is the most common form of joint damage and a major cause of morbidity and disability. The significant increase in the incidence is due to the rapid aging of the population and the pandemic of obesity. The main clinical symptoms of OA are pain and deformation of joints, leading to functional impairment. OA treatment requires not only accurate diagnosis, but also estimation of the prevalence and severity of articular damage, the general health status of the patient and the presence of comorbid conditions for the correct choice of treatment, and possibly a combination thereof. Proven effectiveness of chondroitin sulfate and glucosamine hydrochloride alone, created the preconditions for the development of complex products. The effectiveness of this combination is supported by experimental and clinical data.
About the Author
L I Alekseevad.m.n., zav. otdelom metabolicheskikh zabolevaniy kostey i sustavov s Tsentrom profilaktiki osteoporoza (MZ RF)
References
1. Gore M., Sadosky A., Tai K.-S. et al. Clinical comorbidities, painrelated pharmacotherapy and direct medical costs of pts with OA in clinical practice // OA&Cartil, v.18 suppl 2 Oct 2010. Abst #281 (S126).
2. W. Zhang, G. Nuki, R. Moskowitz et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. OA Cartil, 2010 18(4) 476-99.
3. Zhang W., Moskowitz R.W., Nuki G., et al. OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008; 16: 137-62.
4. Zhang W., Nuki G., Moskowitz R.W., et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010; 18: 476-99.
5. Ronca F., Palmieri L., Panicucci P., Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage. 1998; 6 Suppl A: 14-21.
6. Towheed T.E., Maxwell L., Anastassiades T.P., et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005(2): CD002946.
7. McAlindon T.E., LaValley M.P., Gulin J.P., Felson D.T. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000; 283(11): 1469-75.
8. Schneider H., Maheu E., Cucherat M. Symptom-Modifying Effect of Chondroitin Sulfate in Knee Osteoarthritis: A Meta-Analysis of Randomized Placebo-Controlled Trials Performed with Structum® Open Rheumatol J. 2012; 6: 183-189.
9. Michel B.A., Stucki G., Frey D. и соавт. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Arthritis Rheum. 2005; 52(3): 779-86.
10. Kahan A., Uebelhart D., De Vathaire F. и соавт. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebocontrolled trial. Arthritis Rheum. 2009; 60(2): 524-33.
11. Hochberg M.C. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage. 2010; 18 Suppl 1: S28-31.
12. Das A. Jr., Hammad T.A. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep; 8(5): 343-50.
13. Clegg D.O., Reda D.J., Harris C.L., и соавт. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N. Engl. J. Med. 2006; 354(8): 795-808.
14. Беневоленская Л.И., Алексеева Л.И., Зайцева Е.М. Эффективность препарата терафлекс у больных остеоартрозом коленных и тазобедренных суставов (открытое рандомизированное исследование) РМЖ 2005, Т13, № 8(232), с. 525-527.
15. Алексеева Л.И., Н.Г. Кашеварова, Е.П. Шарапова, Е.М. Зайцева,М.В.Северинова. Сравнение постоянного и интермиттирующего лечения больных остеоартрозом коленных суставов комбинированным препаратом «Терафлекс» Научно-практическая ревматология 2008; № 3, с. 68-72.
Review
For citations:
Alekseeva L.I. COMBINATION THERAPY IN THE TREATMENT OF OSTEOARTHRITIS. THE EFFECTIVENESS OF THERAFLEX. Osteoporosis and Bone Diseases. 2012;15(3):32-35. (In Russ.)
Views:
520
Email this article 
