THE ROLE OF MYOKINES INTERSTITIAL INTERACTION AND REGULATION OF METABOLISM: A REVIEW OF LITERATURE
Abstract
Myokines are hormone-like acting molecules produced in skeletal muscles during and immediately after exercise. They affect both paracrine (inside the muscles themselves) and endocrine manner (in adipose tissue, liver, endothelium, skin, mucosa etc.) implementing different effects on target tissues, mainly through regulation of metabolic processes (such as glucose and lipid metabolism, growth and division of neurons and endothelial cells and others). The examination of myokines is of great interest for researchers of different medicine departments, particularly for endocrinologists, because of myokines’ involvement in pathogenesis of abdominal and visceral obesity, diabetes mellitus type 2 and cardiovascular diseases that are all the components of metabolic syndrome. The most important issue for clinicians is a possibility of future therapeutic implication of the myokine’s signal pathways in treatment of widespread metabolic disorders.
References
1. Pedersen BK, Åkerström TC, Nielsen AR, et al. Role of myokines in exercise and metabolism. J Appl Physiol (1985). 2007 Sep;103(3): 1093-1098. doi: 10.1152/ japplphysiol.00080.2007. Epub 2007 Mar 8.
2. Гребенникова Т.А., Белая Ж.Е., Цориев Т.Т., и др. Эндокринная функция костной ткани // Остеопороз и остеопатии. - 2015. - №1. - С. 28-37. [Grebennikova TA, Belaya ZhE, Tsoriev TT, et al. Endocrine function of bone tissue. Osteoporoz i osteopatii. 2015;(1):28-37. (In Russ)]
3. Белая Ж. Е., Смирнова О. М., Дедов И. И. Роль физических нагрузок в норме и при сахарном диабете // Проблемы эндокринологии. - 2005. - Т.51. - №2. - С. 28-37. [Belaya ZhE, Smirnova OM, Dedov II. Rol’ fizicheskikh nagruzok v norme i pri sakharnom diabete. (Role of exercise in health and in diabetes mellitus.) Problemy endokrinologii. 2005;51(2):28-37. (In Russ)]
4. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88:1379-1406. doi:10.1152/physrev.90100.2007.
5. Pedersen BK. The diseasome of physical inactivity and the role of myokines in muscle-fat cross talk. J Physiol. 2009;587(Pt 23):5559-5568. doi: 10.1113/jphysiol.2009.179515. Epub 2009 Sep 14. Review.
6. Borg SA, Kerry KE, Baxter L, et al. Expression of interleukin-6 and its effects on growth of HP75 pituitary tumour cells. J Clin Endocrinol Metab. 2003;88:4938-4944. doi: 10.1210/jc.2002-022044.
7. van Hall G, Steensberg A, Sacchetti M, et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab. 2003;88:3005-3010. doi: 10.1210/ jc.2002-021687.
8. Kelly M, Keller C, Avilucea PR, et al. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun. 2004;320:449-454. doi: 10.1016/j.bbrc.2004.05.188.
9. Wallenius V, Wallenius K, Ahrén B, et al. Interleukin- 6-deficient mice develop mature-onset obesity. Nat Med. 2002;8:75-79. doi: 10.1038/nm0102-75.
10. Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53:1643-1648.
11. Banzet S, Koulmann N, Simler N, et al. Control of gluconeogenic genes during intense/prolonged exercise: hormone-independent effect of muscle-derived IL-6 on hepatic tissue and PEPCK mRNA. J Appl Physiol. 2009; 107: 1830-1839. doi:10.1152/japplphysiol.00739.2009.
12. Bouzakri K, Plomgaard P, Berney T, et al. Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. Diabetes. 2011;60:1111-1121. doi:10.2337/db10-1178.
13. Gopurappilly R, Bhonde R. Can multiple intramuscular injections of mesenchymal stromal cells overcome insulin resistance offering an alternative mode of cell therapy for type 2 diabetes? Med Hypotheses. 2012;78:393-395. doi:10.1016/j. mehy.2011.11.021.
14. Ellingsgaard H, Hauselmann I, Schuler B, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17:1481-1489. doi:10.1038/nm.2513.
15. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, et al. Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol. 1997;82:1662-1667.
16. Pedersen BK, Steensberg A, Fischer C, et al. Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil. 2003;24:113-119.
17. Pedersen L, Pilegaard H, Hansen J, et al. Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression. J Physiol. 2011;589:1409-1420. doi:10.1113/jphysiol.2010.200733.
18. Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463-468. doi:10.1038/nature10777.
19. Uldry M, Yang W, St-Pierre J, et al. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. CellMetab. 2006 May;3(5):333-341. doi: 10.1016/j.cmet.2006.04.002.
20. Arany Z, He H, Lin J, et al. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr;1(4):259-271. doi: 10.1016/j.cmet.2005.03.002.
21. Lin J, Wu PH, Tarr PT, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1): 121-135. doi: 10.1016/j. cell.2004.09.013.
22. Cui S, Tanabe O, Lim KC, et al. PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol. 2014 Jun;34(11): 1956-1965. doi: 10.1128/MCB.00247-14. Epub 2014 Mar 24.
23. Ma D, Li S, Lucas EK, et al. Neuronal inactivation of peroxisome proliferator-activated receptor y coactivator 1a (PGC-1 a) protects mice from diet-induced obesity and leads to degenerative lesions. JBiolChem. 2010 Dec 10;285(50):39087-39095. doi: 10.1074/jbc.M110.151688. Epub 2010 Oct 13.
24. Rana KS, Arif M, Hill EJ, et al. Plasma irisin levels predict telomere length in healthy adults. Age (Dordr). 2014 Apr;36(2):995-1001. doi: 10.1007/s 11357-014-9620-9. Epub 2014 Jan 29.
25. Gaussin V, Depre C. Myostatin, the cardiac chalone of insulin-like growth factor-1. Cardiovasc Res. 2005;68:347-349. doi: 10.1016/j.cardiores.2005.09.007.
26. Shyu KG, Ko WH, Yang WS, et al. Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes. Cardiovasc Res. 2005;68:405-414. doi: 10.1016/j.cardiores.2005.06.028.
27. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387:83-90. doi: 10.1038/387083a0.
28. Sharma M, Kambadur R, Matthews K, et al. Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct. J Cell Physiol. 1999;180:1-9. doi: 10.1002/ (SICI)1097-4652(199907)180:1<1::AID-JCP1>3.0.CO;2-V.
29. Kanzleiter T, Rath M, Görgens SW, et al. The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochem Biophys Res Commun. 2014 Jul 25;450(2): 1089-1094. doi: 10.1016/j.bbrc.2014.06.123. Epub 2014 Jul 1.
30. Karstoft K, Pedersen BK. Skeletal muscle as a gene regulatory endocrine organ. Curr Opin Clin Nutr Metab Care. 2016 Jul;19(4):270-275. doi: 10.1097/ MCO.0000000000000283.
31. Seidler DG, Mohamed NA, Bocian C, et al. The role for decorin in delayed-type hypersensitivity. J Immunol. 2011 Dec 1 ;187(11):6108-6119. doi: 10.4049/jimmunol. 1100373. Epub 2011 Oct 31.
32. Kalamajski S, Oldberg A. The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol. 2010 May;29(4):248-253. doi: 10.1016/j.matbio.2010.01.001. Epub 2010 Jan 18.
33. Järveläinen H, Puolakkainen P, Pakkanen S, et al. A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen. 2006 Jul-Aug; 14(4):443-452. doi: 10.1111/j.1743-6109.2006.00150.x
34. Merline R, Lazaroski S, Babelova A, et al. Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J Physiol Pharmacol. 2009 Oct;60 Suppl 4:5-13.
35. Rentz TJ, Poobalarahi F, Bornstein P, et al. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem. 2007 Jul 27;282(30):22062-22071. Epub 2007 May 23.
36. Delany AM, Kalajzic I, Bradshaw AD, et al. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 2003 Jun;144(6):2588-2596. doi: 10.1210/en.2002-221044
37. Machado do Reis L, Kessler CB, Adams DJ, et al. Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice. Bone. 2008 Aug;43(2):264-273. doi: 10.1016/j. bone.2008.03.024. Epub 2008 Apr 13.
38. Boskey AL, Moore dJ, Amling M, et al. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003 Jun;18(6):1005-1011. doi: 10.1359/jbmr.2003.18.6.1005
39. Mendoza-Londono R, Fahiminiya S, Majewski J, et al. Recessive osteogenesis imperfecta caused by missense mutations in SPARC. Am J Hum Genet. 2015 Jun 4;96(6):979-985. doi: 10.1016/j.ajhg.2015.04.021. Epub 2015 May 28.
40. Kapinas K, Lowther KM, Kessler CB, et al. Bone matrix osteonectin limits prostate cancer cell growth and survival. Matrix Biol. 2012 Jun;31(5):299-307. doi: 10.1016/j. matbio.2012.03.002. Epub 2012 Apr 16.
41. Aoi W, Naito Y, Takagi T, et al. A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. Gut. 2013 Jun;62(6):882-889. doi: 10.1136/gutjnl-2011-300776. Epub 2012 Jul 31.
42. Шишкин А.Н., Кирилюк Д.В. Дисфункция эндотелия у пациентов с прогрессирующими заболеваниями почек // Нефрология. - 2005. - Т. 9. - №2. - С. 16-22. [Shishkin AN, Kirilyuk DV. Endothelial dysfunction in patients with progressive renal disease. Nephrology. 2005;9(2): 16-22. (In Russ)
43. Nielsen AR, Pedersen BK. The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15. Appl Physiol Nutr Metab. 2007 Oct;32(5):833-839. doi: 10.1139/H07-054. Review.
44. Nielsen AR, Mounier R, Plomgaard P, et al. Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. J Physiol. 2007 Oct 1;584(Pt 1):305-312. doi: 10.1113/jphysiol.2007.139618. Epub 2007 Aug 9.
45. Nielsen AR, Hojman P, Erikstrup C, et al. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J Clin Endocrinol Metab. 2008 Nov;93(11):4486-93. doi: 10.1210/jc.2007-2561. Epub 2008 Aug 12.
46. Quinn LS, Anderson BG, Strait-Bodey L, et al. Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J PhysiolEndocrinolMetab. 2009 Jan;296(1):191-202. doi: 10.1152/ajpendo.90506.2008. Epub 2008 Nov 11.
47. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004 Oct;27(10):589-594. doi: 10.1016/j.tins.2004.08.001
48. Tyler WJ, Alonso M, Bramham CR, et al. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem. 2002 Sep-Oct;9(5):224-237. doi: 10.1101/lm.51202. Review.
49. Connor B, Young D, Yan Q, et al. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):71-81.
50. Laske C, Stransky E, Leyhe T, et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm (Vienna). 2006 Sep; 113(9): 1217-1224. doi: 10.1007/ s00702-005-0397-y. Epub 2005 Dec 16.
51. Manni L, Nikolova V, Vyagova D. Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes. Int J Cardiol. 2005;102:169-171. doi: 10.1016/j. ijcard.2004.10.041.
52. Krabbe KS, Nielsen AR, Krogh-Madsen R, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50:431-438. doi: 10.1007/s00125-006-0537-4. Epub 2006 Dec 7.
53. Karege F, Perret G, Bondolfi G, et al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109:143-148.
54. Matthews VB, Aström MB, Chan MH, et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia. 2009;52:1409-1418. doi: 10.1007/s00125-009-1364-1. Epub 2009 Apr 22.
55. Nieman DC, Henson DA, Smith LL, et al. Cytokine changes after marathon race. J Appl Physiol. 2001;91:109-114.
56. Akerström TC, Steensberg A, Keller P, et al. Exercise induces interleukin-8 expression in human skeletal muscle. J Physiol. 2005;563:507-516. doi: 10.1113/ jphysiol.2004.077610. Epub 2004 Dec 23.
57. Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol. 2010;2010:520258. doi:10.1155/2010/520258. Epub 2010 Mar 9.
58. Гребенникова ТА., Белая Ж.Е., Рожинская Л.Я., и др. Эпигенетические аспекты остеопороза // Вестник РАМН. -2015. - Т. 5. - С. 541-548. [Grebennikova TA, Belaya ZhE, Rozhinskaya LYa, et al. Epigenetic Aspects of Osteoporosis. Vestnik RAMN. 2015;5:541-548. (In Russ)]. doi:10.15690/ vramn.v70.i5.1440.
Review
For citations:
Tsoriev T.T., White Zh.E., Rozhinskaya L.Ya. THE ROLE OF MYOKINES INTERSTITIAL INTERACTION AND REGULATION OF METABOLISM: A REVIEW OF LITERATURE. Osteoporosis and Bone Diseases. 2016;19(1):28-34. (In Russ.)
Views:
5504
Email this article 
