Osteonecrosis of the lower jaw as a complication of antiresorptive therapy

Abstract

The article is a description of a clinical case of osteonecrosis of the mandible in a patient receiving antiresorptive therapy on the background of breast and thyroid cancer (diagnosis was established in 2011). A year later, courses of chemotherapeutic treatment were started, zoledronic acid 4 mg was administered parenterally, and then Denosumab 120 mg. 9 years after the start of chemotherapy in the clinic at the place of residence, the patient’s teeth 4.4 and 4.5 were removed, within two months there were no signs of healing of the bone wound, in connection with which the dentist-surgeon performed an audit of the sockets of the extracted teeth, which provoked a deterioration in the condition of the tissues of oral cavity, decreased quality of life of the patient. Four months after the extraction of teeth 4.4 and 4.5 the patient turned to the dental clinic of the Tver State Medical University, where she is stil lreceiving complex antibacterial, anti-inflammatory and restorative treatment. The patient’s well-being and quality of life have been improved.