ОСТЕОПОРОЗ, ДЕПРЕССИЯ И ПЕРЕЛОМЫ. СОВРЕМЕННЫЕ АСПЕКТЫ ПРОБЛЕМЫ

Для изучения взаимосвязей остеопороза, депрессии и переломов проанализировано более 200 публикаций, для анализа отобрано 124. Остеопороз (ОП) и депрессивное расстройство (ДР) имеют несколько общих факторов риска, биологических, психологических и психосоциальных факторов, ассоциированных с обоими заболеваниями. Патогенез ОП и ДР тесно взаимосвязан. ОП и переломы ведут к развитию ДР, ухудшающего реабилитацию и снижающего приверженность терапии ОП, а ДР, в свою очередь, ассоциировано со снижением МПК, падениями и увеличением риска переломов. Целенаправленное выявление и лечение ДР у пациентов с ОП, так же как выявление и лечение ОП у пациентов с депрессией, должны стать неотъемлемой частью общемедицинской практики. Остаётся много открытых для изучения аспектов взаимосвязей ОП, ДР и переломов.

1. Закроева А.Г., Андриянова О.В., Солодовников А.Г. Сравнительное исследование показателей психического здоровья и их ассоциаций с факторами риска хронических неинфекционных заболеваний в сельской и городской популяциях. Уральский медицинский журнал 2009 2[56], с. 83-93.

2. Закроева А.Г., Андриянова О.В., Солодовников А.Г. Исследование качества жизни, распространённости тревожных и депрессивных расстройств у сельского населения Свердловской области Уральский медицинский журнал. 2007. № 11[39]. Приложение к журналу. С. 7-10.

3. Остеопороз / под ред. О.М. Лесняк, Л.И. Беневоленской. - 2-е изд., перераб. и доп. - М. : ГЭОТАР-Медиа, 2009. - 272 с.

4. Altindag O., Altindag A., Asoglu M., Gunes M., Soran N., Deveci Z. Relation of cortisol levels and bone mineral density among premenopausal women with major depression. Int J Clin Pract. 2007 Mar; 61(3): 416-20.

5. Ang Q.Q., Wing Y.K., He Y., Sulaiman A.H., Chiu N.Y., Shen Y.C., Wang G., Zhang C., Lee K.H., Singh P. Association between painful physical symptoms and clinical outcomes in East Asian patients with major depressive disorder: a 3-month prospective observational study. Int J Clin Pract. 2009 Jul; 63[7]: 1041-9.

6. Bab I.A., Yirmiya R., Depression and bone mass. Ann NY Acad Sci. 2010, Mar: 1: 1192 [1].

7. Bab I.A., Yirmiya R., Depression, selective serotonin inhibitors and osteoporosis. Curr Osteoproros Rep 2010 Sep 1.

8. Bair M.J., Wu J., Damush T.M., Sutherland J.M., Kroenke K. Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom Med. 2008 Oct; 70[8]: 890-7.

9. Bakhtiyarova S., Lesnyak O., Kyznesova N., Blankenstein M.A., Lips P. Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporos Int. 2006; 17[3]: 441-6.

10. Barca M.L., Selbaek G., Laks J., Engedal K. Factors associated with depression in Norwegian nursing homes. Int J Geriatr Psychiatry. 2009 Apr; 24[4]: 417-25.

11. Barnard K., Colón-Emeric C. Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition. Am J Geriatr Pharmacother. 2010 Feb; 8[1]: 4-33.

12. Berk M., Sanders K.M., Pasco J.A., Jacka F.N., Williams L.J., Hayles A.L., Dodd S. Vitamin D deficiency may play a role in depression. Med Hypotheses. 2007; 69[6]: 1316-9. Epub 2007 May 11.

13. Blum M., Harris S.S., Must A., Naumova E.N., Phillips S.M., Rand W.M., Dawson-Hughes B. Leptin, body composition and bone mineral density in premenopausal women. Calcif Tissue Int 2003; 73: 27-32.

14. Brown E.S. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann N Y Acad Sci. 2009 Oct; 1179: 41-55.

15. Cauley J., Fullman R., Stone R., Factors associated with the lumbar spine and proximal femur BMD in older men. Osteoporosis Int 2007: 16: 1525-1537.

16. Chang-Quan H., Xue-Mei Z., Bi-Rong D., Zhen-Chan L., Ji-Rong Y., Qing-Xiu L. Health status and risk for depression among the elderly: a meta-analysis of published literature. Age Ageing. 2010 Jan; 39[1]: 23-30.

17. Cizza G., Nguyen V.T., Eskandari F., Duan Z., Wright E.C., Reynolds J.C., Ahima R.S., Blackman M.R., POWER Study Group. Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression [POWER] study. J Clin Psychiatry. 2010 Aug; 71[8]: 1079-87.

18. Cizza G., Primma S., Coyle M., Gourgiotis L., Csako G Depression and osteoporosis: a research synthesis with meta-analysis. Horm Metab Res. 2010 Jun; 42[7]: 467-82.

19. Cizza G. Major depressive disorder is a risk factor for low bone mass, central obesity, and other medical conditions. Dialogues Clin Neurosci. 2011; 13[1]: 73-87.

20. Coelho R., Silva C., Maia A., Prata J., Barros H. Bone mineral density and depression: a community study in women. J Psychosom Res. 1999 Jan; 46(1): 29-35.

21. Cole M.G., Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am J Psychiatry. 2003 Jun; 160[6]: 1147-56.

22. De Laet C., Kanis J.A., Oden A. et al. Body mass index as a predictor of fracture risk: a meta-analysis // Osteoporosis Int. - 2005. -№ 16. - P. 1330-1338.

23. Devenand D.P. Comorbid psychiatric illness in late life depression. Biol Psychiatry 2002; 52: 236-42.

24. Diem S.J., Blackwell T.L., Stone K.L., Yaffe K., Cauley J.A., Whooley M.A., Ensrud K.E.; Study of Osteoporotic Fractures Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc. 2007 Jun; 55[6]: 824-31.

25. Diem S.J. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med. 2007; 167: 1240-1245.

26. Djernes J.K. Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand. 2006 May; 113[5]: 372-87.

27. adolescent girls. Arch Pediatr Adolesc Med. 2008; 162: 1181-1188.

28. Eskandari F Duan Z., Wright E.C., Reynolds J.C., Ahima R.S., Blackman M.R., Low bone mass in premenopausal women with depression. Arch Intern Med. 2007; 167: 2а9-2336.

29. Forsen L., H. E. Meyer, A. J. Sogaard, S. Naess, B. Schei, and T. H. Edna Mental distress and risk of hip fracture. Do broken hearts lead to broken bones? J Epidemiol Community Health. 1999 June; 53[6]: 343-347.

30. Furlan P.M., Ten Have T., Cary M., Zemel B., Wehrli F., Katz I.R., Gettes D.R., Evans D.L. The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density. Biol Psychiatry. 2005 Apr 15; 57(8): 911-7.

31. Ganesan K., Teklehaimanot S., Tran T.H., Asuncion M., Norris K. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc. 2005 Mar; 97 [3]: 329-33.

32. Golier J.A., Yehuda R., Bierer LM., Mitropoulou V., New A.S., Schmeidler J., Silverman J.M., Siever LJ. The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events. Am J Psychiatry 2003; 160: 2018-24.

33. Greendale G., Unger J., Rower J. The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur Studies. J Am Geriartr Soc. 1999. 47: 799-803

34. Hadjidakis D., Tsagarakis S., Roboti C., Sfakianakis M., Iconomidou V., Raptis S.A., Thalassinos N. Does subclinical hypercortisolism adversely affect the bone mineral density of patients with adrenal incidentalomas? Clin Endocrinol [Oxf] 2003; 58: 72-7.

35. Haney E., Chan B., Diem S., Associations of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Int Med 2007: 167 1246-1251.

36. Haney E.M., Bliziotes M.M. Male osteoporosis: new insights in an understudied disease. Curr Opin Rheumatol. 2008; 20: 423-428.

37. Hartman J.M., Berger A., Baker K., Bolle J., Handel D., Mannes A., Pereira D., St Germain D., Ronsaville D., Sonbolian N., Torvik S., Calis K.A., Phillips T.M., Cizza G.; PO.W.E.R. [Premenopausal, Osteoporosis, Women, Alendronate, Depression] Study Group. Quality of life and pain in premenopausal women with major depressive disorder: the POWER Study. Health Qual Life Outcomes. 2006 Jan 18; 4: 2.

38. Herrán A., Amado J.A., García-Unzueta M.T., Vázquez-Barquero J.L., Perera L., González-Macías J. Increased bone remodeling in first-episode major depressive disorder Psychosom Med. 2000 Nov-Dec; 62[6]: 779-82.

39. Heuser I. The hypothalamic-pituitary-adrenal axis in depression. Pharmacopsychiatry 1998; 31: 10-3.

40. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009 Feb; 71[2]: 171-86.

41. Huang C.Q., Dong B.R., Lu Z.C., Yue J.R., Liu Q.X. Chronic diseases and risk for depression in old age: a meta-analysis of published literature. Ageing Res Rev. 2010 Apr; 9[2]: 131-41. Epub 2009 Jun 11.

42. Huang K.-C., Cheng W.-C., Yen R.-F., Tsai K.-S., Tai T.-Y., Yang W.-S. Lack of independent relationship between plasma adiponectin, leptin levels and bone density in nondiabetic female adolescents. Clin Endocrinol 2004; 61: 204-8.

43. Hubbard R., Farrington P., Smith C., Smeeth L., Tattersfield A. Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol. 2003 Jul 1; 158(1): 77-84.

44. Huijbregts K.M., van der Feltz-Cornelis C.M., van Marwijk H.W., de Jong F.J., van der Windt D.A., Beekman A.T. Negative association of concomitant physical symptoms with the course of major depressive disorder: a systematic review. J Psychosom Res. 2010 Jun; 68[6]: 511-9.

45. Iwamoto I., Oouchi T., Kosha A., Murakami M., Fujino T., Nagata Y. Relationships between serum leptin level and regional bone mineral density, bone metabolic markers in healthy women. Acta Obstet Gynecol Scand 2000; 79: 1060-4.

46. Jacka F.N., Pasco J.A., Henry M.J., Kotowicz M.A., Dodd S., Nicholson G.C., Berk M. Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study. J Menopause. 2005 Jan-Feb; 12(1): 88-91.

47. Jain R. The epidemiology and recognition of pain and physical symptoms in depression. J Clin Psychiatry. 2009 Mar 9; 70[3]: e04.

48. Jorde R., Sneve M., Figenschau Y., Svartberg J., Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med. 2008 Dec; 264[6]: 599-609. Epub 2008 Sep 10.

49. Kahl K.G., Bens S., Ziegler K., Rudolf S., Dibbelt L., Kordon A., Schweiger U. Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder. Biol Psychiatry

50. Kai G., Kahl, M.D., Sebastian Rudolf, Beate M. Stoeckelhuber, M.D., Leif Dibbelt, M.D., Hans-Björn Gehl, M.D., Kerstin Markhof, Fritz Hohagen, M.D., and Ulrich Schweiger, M.D. Bone Mineral Density, Markers of Bone Turnover, and Cytokines in Young Women With Borderline Personality Disorder With and Without Comorbid Major Depressive Disorder Am J Psychiatry 162: 168-174, January 2005 © 2005 American Psychiatric Association.

51. Kanis J.A., Johansson H., Johnell O., Oden A., De Laet C., Eisman J.A., Pols H., Tenenhouse A. Alcohol intake as a risk factor for fracture. Osteoporos Int. 2005 Jul; 16(7): 737-42. Epub 2004 Sep 29.

52. Kanis J.A., Johnell O., Oden A., Johansson H., De Laet C., Eisman J.A., Fujiwara S., Kroger H., McCloskey E.V., Mellstrom D., Melton L.J., Pols H., Reeve J., Silman A., Tenenhouse A. Smoking and fracture risk: a metaanalysis. Osteoporos Int. 2005 Feb; 16(2): 155-62. Epub 2004 Jun 3.

53. Kanis J.A., Johanson H., Oden A., Johnell O. A meta-analysis of prior corticosteroid use and fracture risk // J. Bone Miner. Res. - 2000. - № 19. - P. 893-899.

54. Kavuncu V., Kuloglu M., Kaya A., Sahin S., Atmaca M., Firidin B. Bone metabolism and bone mineral density in premenopausal women with mild depression. Yonsei Med J. 2002 Feb; 43(1): 101-8.

55. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., Rush A.J., Walters E.E., Wang P.S.; National Comorbidity Survey Replication The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication [NCS-R]. JAMA. 2003 Jun 18; 289[23]: 3095-105.

56. Kinjo M., Setoguchi S., Schneeweiss S., Solomon D.H. Bone mineral density in subjects using central nervous system-active medications Am J Med 2005: 118 1414. e7-1414e12.

57. Koopmans P.C., Roelen C.A., Bültmann U., Hoedeman R., van der Klink J.J., Groothoff J.W. Gender and age differences in the recurrence of sickness absence due to common mental disorders: a longitudinal study. BMC Public Health. 2010 Jul 20; 10: 426. Epub 2010 Jul 20.

58. Kop W.J., Stein P.K., Tracy R.P., Barzilay J.I., Schulz R., Gottdiener J.S. Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med. 2010 Sep; 72[7]: 626-35.

59. Korpelainen R., Korpelainen J., Heikkinen J., Väänänen K., Keinänen-Kiukaanniemi S. Lifelong risk factors for osteoporosis and fractures in elderly women with low body mass index--a population-based study. Bone. 2006; 39: 385-391.

60. Kraus T. Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology. 2001; 73: 243-247.

61. Lam J., Takeshita S., Barker J.E., Kanagawa O., Ross F.P., Teitelbaum S.L. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000; 106: 1481-8.

62. Lanqillon S., Krieg J.-C., Bening-Abu-Shach U., Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 2000; 22: 370-9.

63. Lee D.M., Tajar A., O’Neil T.W. Lower vitamin D levels are associated with depression among community dwelling European men. J Psychopharmacol. 2010 Sep 7.

64. Lee P., Zhang M., Hong J.P., Chua H.C., Chen K.P., Tang S.W., Chan B.T., Lee M.S., Lee B., Gallagher G.L., Dossenbach M. Frequency of painful physical symptoms with major depressive disorder in asia: relationship with disease severity and quality of life. J Clin Psychiatry. 2009 Jan; 70[1]: 83-91.

65. Legenbauer T., De Zwaan M., Benecke A., Muhlhans B., Petrak F., Herpertz S. Depression and anxiety: their predictive function for weight loss in obese individuals. Obes Facts. 2009; 2[4]: 227-34.

66. Lépine J.P., Briley M. The increasing burden of depression. Neuropsychiatr Dis Treat. 2011; 7[Suppl 1]: 3-7. Epub 2011 May 31.

67. Lieb K., Rexhausen J.E., Kahl K.G., Schweiger U., Philipsen A., Hellhammer D.H., Bohus M. Increased diurnal salivary cortisol in women with borderline personality disorder. J Psychiatr Res 2004; 38: 559-65.

68. Lopez-Duran N.L., Kovacs M., George C.J. Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: a meta-analysis. Psychoneuroendocrinology. 2009 Oct; 34[9]: 1272-83. Epub 2009 May 5.

69. Luppino F.S., de Wit L.M., Bouvy P.F., Stijnen T., Cuijpers P., Penninx B.W., Zitman F.G. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010 Mar; 67(3): 220-9.

70. Mezuk B., Eaton W.W., Golden S.H. Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int. 2008 Jan; 19[1]: 1-12.

71. Michelson D. Stratakis C., Hill L., Reynolds J., Galliven E., Chrousos G., Gold P. Bone mineral density in women with depression. N Engl J Med. 1996 Oct 17; 335[16]: 1176-81.

72. Milaneschi Y., Serum 25-hydroxyvitamin D and depressive symptoms in older women and men.J Clin Endocrinol Metab. 2010 Jul; 95[7]: 3225-33. Epub 2010 May 5.

73. Milliken.L.A., Wilhelmy J., Martin C.J., Finkenthal N., Cussler E., Metcalfe L., Guido T.A., Going S.B., Lohman T.G. Depressive symptoms and changes in body weight exert independent and site-specific effects on bone in postmenopausal women exercising for 1 year. Gerontol A Biol Sci Med Sci. 2006 May; 61[5]: 488-94.

74. Moreland J.D., Richardson J.A., Goldsmith C.H., Clase C.M. Muscle weakness and falls in older adults: a systematic review and meta-analysis // J. Am. Geriatr. Soc. - 2004. - № 52. - P. 1121-1129.

75. Muhsen K., Lipsitz J., Garty-Sandalon N., Gross R., Green M.S. Correlates of generalized anxiety disorder: independent of comorbidity with depression: Findings from the first Israeli National Health Interview Survey [2003-2004] Soc Psychiatry Psychiatr Epidemiol. 2008; 43: 898-904.]

76. Mussolino M.E. Depression and bone mineral density in young adults: results from NHANES III. Psychosom Med. 2004; 66: 533-537. [PubMed].

77. Mussolino M.E. Depression and hip fracture risk: the NHANES I epidemiologic follow-up study. Public Health Rep. 2005; 120: 71-75.

78. Nurminen J., Puustinen J., Piirtola M., Vahlberg T., Kivelä S.L. Psychotropic drugs and the risk of fractures in old age: a prospective population-based study BMC Public Health. 2010 Jul 6; 10: 396.

79. Paudel M.L., Taylor B.C., Diem S.J., Stone K.L., Ancoli-Israel S., Redline S., Ensrud K.E.; Osteoporotic Fractures in Men Study Group. Association between depressive symptoms and sleep disturbances in community-dwelling older men. Am Geriatr Soc. 2008 Jul; 56[7]: 1228-35.

80. Peppone L.J., Huston A.J., Reid M.E., Rosier R.N., Zakharia Y., Trump D.L., Mustian K.M., Janelsins M.C., Purnell J.Q., Morrow G.R. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Treat. 2011 May; 127[1]: 171-7. Epub 2011 Mar 8.

81. Perugi G., Canonico P.L., Carbonato P., Mencacci C., Muscettola G., Pani L., Torta R., Vampini C., Fornaro M., Parazzini F., Dumitriu A.; Come To Me Study Group / Unexplained somatic symptoms during major depression: prevalence and clinical impact in a national sample of Italian psychiatric outpatients. Psychopathology. 2011; 44[2]: 116-24.

82. Petronijević M., Petronijević N., Ivković M., Stefanović D., Radonjić N., Glisić B., Ristić G., Damjanović A., Paunović V. Low bone mineral density and high bone metabolism turnover in premenopausal women with unipolar depression. Bone. 2008; 42: 582-590.

83. Priitola M., Vahlberg T., Isoaho R., AArino P., Kivela S.L., Predictors of fractures among the aged: a population-based study with 12-year follow-up in Finnish municipality. Aging Clin Exp Res 20[3]: 242-252.

84. Rait G., Walters K., Griffin M., Buszewicz M., Petersen I., Nazareth I. Recent trends in the incidence of recorded depression in primary care. Br J Psychiatry. 2009 Dec; 195[6]: 520-4.

85. Rauch F., Blum W.F., Klein K., Allolio B., Schonau E. Does leptin have an effect on bone in adult women? Calcif Tissue Int 1998; 63: 453-5

86. Reginster J.Y., Deroisy R., Paul I., Hansenne M., Ansseau M. Depression vulnerability is not an independent risk factor of osteoporosis in postmenopausal women. 1999 Maturitas 33: 133-137.

87. Richards J.B., Papaioannou A., Adachi J.D., Joseph L., Whitson H.E., Prior J.C., Goltzman D.; Canadian Multicentre osteoporosis Study Research Group. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med. 2007 Jan 22; 167[2]: 188-94.

88. Robbins J., Hirsch C., Whitmer R., Cauley J., Harris T. The association of bone mineral density and depression in an older population. J Am Geriatr Soc. 2001; 49: 732-736.

89. Sanders K.M., Stuart A.L., Williamson E.J., Jacka F.N., Dodd S., Nicholson G., Berk M. Annual high-dose vitamin D3 and mental well-being: randomised controlled trial. Br J Psychiatry. 2011 May; 198[5]: 357-64.

90. Schlienger R.G. Use of beta-blockers and risk of fractures. Jama. 2004; 292: 1326-1332.

91. Schweiger U., Weber B., Deuschle M., Heuser I. Lumbar bone mineral density in patients with major depression: evidence of increased bone loss at follow-up. Am J Psychiatry 2000; 157: 118-20.

92. Shyu Y.I., Chen M.C., Cheng H.S., Liang J., Wu C.C., Deng C. Wu C.C., Tsai W.C. Severity of depression risk predicts health outcomes and recovery following for hip-fractured elders. osteoporosis Int [2008] 19: 1541-1547.

93. Silverman S.L., Shen W., Minshall M.E., Xie S., Moses K.H. Prevalence of depressive symptoms in postmenopausal women with low bone mineral density and/or prevalent vertebral fracture: results from the Multiple outcomes of Raloxifene Evaluation [MoRE] study. J Rheumatol. 2007 Jan; 34[1]: 140-4.

94. Sogaard A.J., Joakimsen R.M., Tverdal A., Fonnebo V., Magnus J.S., Berntsen G.K.R., Long-term mental distress, bone mineral density and nonvertebral fractures. The Tromso Study. osteoporosis Int 2005 16; 887-897.

95. Spangler L., Scholes D., Brunner R.L., Robbins J., Reed S.D., Newton K.M., Melville J.L., MD, LaCroix A.Z. Depressive symptoms, bone loss, and fractures in postmenopausal women. J Gen Intern Med. 2008; 23 [5]: 567-574. Published online 2008 February 20. doi: 10.1007/ s11606-008-0525-0.

96. Sriwattanakomen R., McPherron J., Chatman J., Morse J.Q., Martire L.M., Karp J.F., Houck P.R., Bensasi S., Houle J., Stack J.A., Woods M., Block B., Thomas S.B., Quinn S., Reynolds C.F. 3rd. A comparison of the frequencies of risk factors for depression in older black and white participants in a study of indicated prevention. Int Psychogeriatr. 2010 Dec; 22[8]: 1240-7.

97. Stetler C., Miller G.E. Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med. 2011 Feb-Mar; 73[2]: 114-26. Epub 2011 Jan 21.

98. Stewart A., Hirani G. Relationship Between Vitamin D Levels and Depressive Symptoms in older Residents From a National Survey Population Psychosom. Med. 2010; 72: 608-612.

99. Stone K.L. Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures // J. Am. Geriatr.Soc. - 2006. - № 54[8]. - P. 1177-1183.

100. Takkouche B., Montes-Martinez A., Gill S.S., Etminan M. Psychotropic medications and the risk of fractures: a meta-analysis // Drug. Saf. - 2007. - Vol. 30[2]. - P. 171-184.

101. Tanaka H., Sasazawa Y., Suzuki S., Nakazawa M., Koyama H. Health status and lifestyle factors as predictors of depression in middle-aged and elderly Japanese adults: a seven-year follow-up of the Komo-Ise cohort study. BMC Psychiatry. 2011 Feb 7; 11: 20.

102. Tolea M.I., Black S.A., Carter-Pokras O.D., Kling M.A. Depressive symptoms as a risk factor for osteoporosis and fractures in older Mexican American women. Osteoporos Int. 2007; 18: 315-322

103. Vaccarino A.L., Sills T.L., Evans K.R., Kalali A.H. Prevalence and association of somatic symptoms in patients with Major Depressive Disorder. J Affect Disord. 2008 0ct; 110[3]: 270-6. Epub 2008 Feb 15.

104. Van der Brand M.W.M., Samson M.M., Pouwels S. T.P. Use of anti-depressants and the risk of fracture of the hip or femur. Osteoporosis Int 2009 20: 1705-1713.

105. Van West D., Maes M. Activation of the inflammatory response system: a new look at the etiopathogenesis of major depression. Neuroendocrinol Lett 1999; 20: 11-7.

106. Vestergaard P., Rejnmark L., Mosekilde L. Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture. Calcif Tissue Int. 2008; 82: 92-101.

107. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - a meta-analysis // Osteoporosis Int. - 2007. - № 18. - P. 427-444.

108. Vestergaard P., Rejnmark L., Mosekilde L. Anxiolytics, sedatives, antidepressants, neuroleptics and risk of fracture. Osteoporosis Int 2006; 17: 807-816.

109. Vickers M.H., Reddy S., Ikenasio B.A., Breier B.H. Dysregulation of the adipoinsular axis - a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming. J Endocrinol 2001; 170: 323-32.

110. Voshaar R.C., Banerjee S., Horan M., Baldwin R., Pendleton N., Proctor R., Tarrier N., Woodward Y., Burns A. Predictors of incident depression after hip fracture surgery. Am J Geriatr Psychiatry. 2007 Sep; 15[9]: 807-14. Epub 2007 Aug 13.

111. Vreeburg S.A., Hoogendijk W.J., van Pelt J., Derijk R.H., Verhagen J.C., van Dyck R., Smit J.H., Zitman F.G., Penninx B.W. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study Arch Gen Psychiatry. 2009 Jun; 66[6]: 617-26.

112. Weyerer S., Eifflaender-Gorfer S., Köhler L., Jessen F., Maier W., Fuchs A., Pentzek M., Kaduszkiewicz H., Bachmann C., Angermeyer M.C., Luppa M., Wiese B., Mösch E., Bickel H.; German AgeCoDe Study group [German Study on Ageing, Cognition and Dementia in Primary Care Patients]. Prevalence and risk factors for depression in non-demented primary care attenders aged 75 years and older J Affect Disord. 2008 Dec; 111[2-3]: 153-63.

113. Whitson H. E., Sanders L., Pieper C.F., Gold D. T., Papaioannou A., Richards J. B., Adachi J. D., Lyles K.W., the CaMos Research Group. Depressive symptomatology and fracture risk in community-dwelling older men and women Aging Clin Exp Res. 2008 December; 20[6]: 585-592.

114. WHO Guide to Mental and Neurological Health in Primary Care. World Health Organization / Ed. Rachel Jenkins. - 2004. - 305 p.

115. Whooley M.A., Kip K.E., Cauley J.A., Ensrud K.E., Nevitt M.C., Browner W.S. Arch Intern Med. Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. 1999 Mar 8; 159[5]: 484-90.

116. Whooley M.A.,Kip K.E., Cauley J.A., Ensrud K.E., Nevitt M.C. Depressive symptoms and bone mineral density in older men. J Geriatr Psychiatry Neurol. 2004; 17: 88-92.

117. Williams D.R., Gonzalez H.M., Neighbors H., Nesse R., Abelson J.M., Sweetman J., Jackson J.S. Prevalence and distribution of major depressive disorder in African Americans, Caribbean blacks, and non-Hispanic whites: results from the National Survey of American Life. Arch Gen Psychiatry. 2007 Mar; 64[3]: 305-15.

118. Witte J. G. Hoogendijk, M.D., PhD; Paul Lips, M.D., PhD; Miranda G. Dik, PhD; Dorly J. H. Deeg, PhD; Aartjan T. F. Beekman, Md, PhD; Brenda W. J. H. Penninx, PhD. Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults Arch Gen Psychiatry. 2008; 65[5]: 508-512.

119. Wong S.Y.S., Lau E.M.C., Lynn H., Leung P.C., Woo J., Cummings S.R., Orwoll E. Depression and bone mineral density: is there a relationship in elderly Asian men? Results from Mr Os Osteoporosis Int 2005 16; 610-615.

120. Wu Q., Liu J., Gallegos-Orozco J.F., Hentz J.G. Depression, fracture risk, and bone loss: a meta-analysis of cohort studies. Osteoporos Int. 2010 Oct; 21[10]: 1627-35. Epub 2010 Mar 4.

121. Yirmiya R., Bab I. Major depression is a risk factor for low bone mineral density: a meta-analysis. Biol Psychiatry, 2009 Sep 1: 66[5]: 423-32.

122. Yu B.H., Kang E.H., Ziegler M.G., Mills P.J., Dimsdale J.E. Mood states, sympathetic activity, and in vivo beta-adrenergic receptor function in a normal population. Depress Anxiety. 2008; 25: 559-564.

123. Zheng S.X., Vrindts Y., Lopez M., De Groote D., Zangerle P.F., Collette J., Franchimont N., Geenen V., Albert A., Reginster J.Y.: Increase in cytokine production [IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF] by stimulated whole blood cells in postmenopausal osteoporosis. Maturitas 1997; 26: 63-71.

124. Ziere G., Dieleman J.P., van der Cammen T.J., Hofman A., Pols H.A., Stricker B.H. Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J Clin Psychopharmacol. 2008; 28: 411-417.