EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza
https://doi.org/10.14341/osteo2007120-24
Abstract
The aim of this study was to assess the effectiveness of the combined treatment with calcium and middle (400 mg daily) or high doses (800 mg daily) of vitamin D for prevention of osteoporosis in postmenopausal women with osteopenia in spine. Thirty patients, 45-70 years old, were divided into 3 equal groups: the women in the group 1 were treated with vitamin D3 400 IU. and calcium 1000 mg daily; the women in the group 2 received vitamin D3 800 IU and calcium 1000 mg daily; the patients from the group 3 did not receive any supplementation - the control 1 group.
A significant increase in BMD was found at lumbar spine (+1.9 % after 6 months, p<0.05) and trochanter (+4.6% after 6 months and +5.5% after 12 months, p<0.01) in the group 1. BMD did not significantly change in all regions of the skeleton in the group 2. However, there was a significant decrease vs. baseline in BMD at lumbar spine (p<0.05), Ward's triangle (p<0.05), trohanter (p<0.05) and total femur (p<0.001) in control group. We found a significant decrease of PTH, serum phosphorus and alkaline phosphatase in both treated groups, and there was a significant increase of PTH, alkaline phosphatase and osteocalcin and a decrease in serum calcium and daily calcium excretion in the control group.
These results demonstrate that combine therapy with calcium and middle or high doses of vitamin D is effective for the prevention of postmenopausal osteoporosis. Moreover, the consumption of the higher doses of vitamin D (800IU) increases BMD at spine and femur in postmenopausal women with osteopenia.
A significant increase in BMD was found at lumbar spine (+1.9 % after 6 months, p<0.05) and trochanter (+4.6% after 6 months and +5.5% after 12 months, p<0.01) in the group 1. BMD did not significantly change in all regions of the skeleton in the group 2. However, there was a significant decrease vs. baseline in BMD at lumbar spine (p<0.05), Ward's triangle (p<0.05), trohanter (p<0.05) and total femur (p<0.001) in control group. We found a significant decrease of PTH, serum phosphorus and alkaline phosphatase in both treated groups, and there was a significant increase of PTH, alkaline phosphatase and osteocalcin and a decrease in serum calcium and daily calcium excretion in the control group.
These results demonstrate that combine therapy with calcium and middle or high doses of vitamin D is effective for the prevention of postmenopausal osteoporosis. Moreover, the consumption of the higher doses of vitamin D (800IU) increases BMD at spine and femur in postmenopausal women with osteopenia.
About the Authors
A V DREVAL'L A MARChENKOVA
I V KRYuKOVA
R S TIShENINA
N V BALAShOVA
L M PORTNOY
N M MYLOV
M P RUBIN
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For citations:
DREVAL' A.V., MARChENKOVA L.A., KRYuKOVA I.V., TIShENINA R.S., BALAShOVA N.V., PORTNOY L.M., MYLOV N.M., RUBIN M.P. EFFEKTIVNOST' PRIMENENIYaKOMBINIROVANNOY TERAPII KAL'TsIEMS VYSOKIMI I SREDNIMI DOZAMI VITAMINA D3dlya profilaktiki postmenopauzal'nogo osteoporoza. Osteoporosis and Bone Diseases. 2007;10(1):20-24. (In Russ.) https://doi.org/10.14341/osteo2007120-24
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