Vol 8, No 1 (2005)
Articles
2-6 569
Abstract
There are considered possible mechanisms of some peculiarities of cosmonauts bone tissue changes after space flights 5-7 month duration, that were diagnosed using dual energy X-ray absoptiometry (DEXA). Local osteopenia in spongy bone of the body lower part may be connected with big weight bearing load in 1g conditions. Increasing of mineral content in upper part of the skeleton and hypermineralization of vertebrae body spongy bone, that were showed by computer tomography possible are the secondary effects and are connected with fluid redistribution to cranial direction, including abdomen.
Additional negative gradient of bone mass in bones of lower part of skeleton, that is observed in early period of readaptation (till 1 month) may be explained as result of acceleration of bone remodeling (resorption and formation of bone), as reaction to recover of loading. Individual variability of above mentioned reactions is connected with genetically determined initial bone mass and phenotype of bone metabolism. There are considered possibilities of genetic prediction of osteopenia in discussed conditions.
Additional negative gradient of bone mass in bones of lower part of skeleton, that is observed in early period of readaptation (till 1 month) may be explained as result of acceleration of bone remodeling (resorption and formation of bone), as reaction to recover of loading. Individual variability of above mentioned reactions is connected with genetically determined initial bone mass and phenotype of bone metabolism. There are considered possibilities of genetic prediction of osteopenia in discussed conditions.
12-15 1724
Abstract
Condition of bone tissue and calcium - phosphorus exchange in patients wish type 1 diabetes mellitus.
Aim: the estimation the calcium - phosphorus exchange and calcium - regulation hormones of absolute insulin insufficient on base measuring.
Materials and methods: were inspected 61 patients wish type 1 diabetes mellitus (age 20 - 50 years) and prolong of disease from 1 to 24 years. All patients got insulin in dose-depending regime. 38 patients were diagnostic decompensate type 1 diabetes mellitus, 18 - subcompensate diabetes mellitus and 5 patients had stage of compensation disease. Control group was consisted by 50 people. All patients were estimated calcium - phosphorus exchange and condition of calcium - regulation hormones.
Results. It is marked the level of calcium (Ca) increase and increase secretion of parathyroid hormone (PTH) and calcitonine (CT) in depending of prolong and during type 1 diabetes mellitus. Increasing of urinasy exretion calcium and phosphor has positive correlation with the glycemia level in the blood in patients with type 1 diabetes mellitus.
Conclusion. It was marked the calcium - phosphorus exchange and increase calcium - regulation hormones levels.
Aim: the estimation the calcium - phosphorus exchange and calcium - regulation hormones of absolute insulin insufficient on base measuring.
Materials and methods: were inspected 61 patients wish type 1 diabetes mellitus (age 20 - 50 years) and prolong of disease from 1 to 24 years. All patients got insulin in dose-depending regime. 38 patients were diagnostic decompensate type 1 diabetes mellitus, 18 - subcompensate diabetes mellitus and 5 patients had stage of compensation disease. Control group was consisted by 50 people. All patients were estimated calcium - phosphorus exchange and condition of calcium - regulation hormones.
Results. It is marked the level of calcium (Ca) increase and increase secretion of parathyroid hormone (PTH) and calcitonine (CT) in depending of prolong and during type 1 diabetes mellitus. Increasing of urinasy exretion calcium and phosphor has positive correlation with the glycemia level in the blood in patients with type 1 diabetes mellitus.
Conclusion. It was marked the calcium - phosphorus exchange and increase calcium - regulation hormones levels.
ISSN 2072-2680 (Print)
ISSN 2311-0716 (Online)
ISSN 2311-0716 (Online)
