Otsenka riska padeniy zhenshchin s postmenopauzal'nymosteoporozom, poluchayushchikh al'fakal'tsidol
https://doi.org/10.14341/osteo2010215-17
Abstract
The study objective: to assess the influence of alfacalcidol treatment
on risk of falling in real clinical practice.
Methods. Prospective cohort study included 46 postmenopausal
women aged from 52 to 78, who had high risk of falling, low bone
mineral density, glomerular filtration rate from 65 to 30 ml/min,
signed informed consent and were naïve to calcium, vitamin D and
antiresorptive agents. All patients have participated in Osteoporosis
Patients School Classes, received prescriptions for daily 1 mcg alfacalcidol
and approved recommendations on lifestyle modifications
including diet, exercises and movement patterns. Individual risk of
falling was assessed with the help of Guralnik Short Physical Performance
Battery Score.
Results. There were no new cases of falling and fractures in the
cohort during 12 months. During the study period 28 women showed
compliance to alfacalcidol 80% or more (group 1), in 15 patients
compliance was less than 80% (group 2) and 3 women decided to
quit the study. Only group 1 demonstrated significant physical function
changes for the better while there were no significant changes
in group 2.
Conclusion. In a group of postmenopausal women with high risk
of falling and fractures, significant positive changes in lower extremity
performance and balance tests were registered only in women
with 80% or higher compliance to alfacalcidol consumption.
on risk of falling in real clinical practice.
Methods. Prospective cohort study included 46 postmenopausal
women aged from 52 to 78, who had high risk of falling, low bone
mineral density, glomerular filtration rate from 65 to 30 ml/min,
signed informed consent and were naïve to calcium, vitamin D and
antiresorptive agents. All patients have participated in Osteoporosis
Patients School Classes, received prescriptions for daily 1 mcg alfacalcidol
and approved recommendations on lifestyle modifications
including diet, exercises and movement patterns. Individual risk of
falling was assessed with the help of Guralnik Short Physical Performance
Battery Score.
Results. There were no new cases of falling and fractures in the
cohort during 12 months. During the study period 28 women showed
compliance to alfacalcidol 80% or more (group 1), in 15 patients
compliance was less than 80% (group 2) and 3 women decided to
quit the study. Only group 1 demonstrated significant physical function
changes for the better while there were no significant changes
in group 2.
Conclusion. In a group of postmenopausal women with high risk
of falling and fractures, significant positive changes in lower extremity
performance and balance tests were registered only in women
with 80% or higher compliance to alfacalcidol consumption.
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For citations:
Strunina M.V., Telyushchenko M.V., Popov A.A., Izmozherova N.V. Otsenka riska padeniy zhenshchin s postmenopauzal'nymosteoporozom, poluchayushchikh al'fakal'tsidol. Osteoporosis and Bone Diseases. 2010;13(2):15-17. (In Russ.) https://doi.org/10.14341/osteo2010215-17
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