BIOCHEMICAL MARKERS OF BONE RESORPTION, REGULATION OF OSTEOCLASTOGENESIS AND BONE LOSS FOLLOWING LIVER TRANSPLANTATION
https://doi.org/10.14341/osteo2013118-23
Abstract
Methods and results: bone densitometry of L2-L4 and neck of femur, the level in serum of blood some hormones (PTH, vitamin D3, estradiol, testosterone) and cytokines (OPG, IL-6, FNO-a) regulating osteoclastogenesis as well as comparative analyses of two bone resorption markers β-crosslaps and tartrate-resistant acid phosphatase type 5b (TRAP-5b) were fulfilled at different periods following orthotopic liver transplantation. At the early date after operation there were the bone density decrease of L2-L4, the lowering of vitamin D3, estradiol in women, testosterone in men and the elevation of cytokines and of resorption markers. In 1 and 2 years following liver transplantation there were revealed the rise of bone density, the level of PTH, estradiol, testosterone, which were associated with the lowering of IL-6, FNO-a and β-crosslaps while the level of vitamin D3 and TRAP-5b remained stable. Conclusion: at the early date TRAP-5b was more specific marker of bone resorption which did not depend on collagen metabolism in liver. In 1 and 2 years following liver transplantation bone resorbtion was association with level of PTH, FNO-a and OPG.
About the Authors
V P BuzulinaI A Pronchenko
I P Ermakova
N P Shmerko
A A Andrianova
M N Kornilov
E B Yaroshenko
T K Koliashvili
References
1. Бузулина В.П., Пронченко И.А., Ермакова И.П. и соавт. Биохимические маркеры ремоделирования костной ткани предикторы динамики костных потерь после пересадки печени // вестник трансплантологии и исскуственных органов 2010 т.12 -. №3 с.52-62.
2. Бузулина В.П., Пронченко И.А., Ермакова И.П. и соавт. Клинические аспекты и биохимические маркеры формирования костной ткани в раннем периоде после пересадки печени //вестник трансплантологии и искусственных органов 2012 т. 14 №1 с. 19-26.
3. Готье С.В., Мойсюк Я.Г., Попцов В.Н. и соавт. Опыт 100 трансплантаций трупной печени в одном центре.//Вестник трансплантологии и искусственных органов 2012 т.14 № 1 с 6-14.
4. Ермакова И.П., Бузулина И.П., Пронченко И.А. и соавт. влияние глюкокортикоидов на костный метаболизм после пересадки печени// тез.докл. 1V всероссийский съезд трансплантологов 9-10 ноября. -2008 с. 148.
5. Atamaz F., Hepculer S., Akuildiz M., Karasu Z. Effects of alendronate on bone mineral density and bone metabolic markers in patients with liver transplantation// Osteoporos Int. 2006 Vol. 17. P. 942-949.
6. Burra P. Sexsual dysfunction after liver transplantation//Liver Transplantation. 2009 Vol.15 P. S50-S56.
7. Crawford B.A.L., Kam C., Pavlovic J., Byth K. et al. Zoledronic acid prevents bone loss after liver transplantation.//Ann.InternMed.2006 Vol. 144 P239-248.
8. Compston J.E. Osteoporosis after liver transplantation.// Liver Transpl. 2003 Vol. 9 P. 321-330.
9. Crosbie O.M., Freaney R., McKenna M.J., Curry M.P., Hegarty J.E. Predicting bone loss following orthotopic liver transplantation//Gut. -1999 Vol.44 P. 430-434.
10. Delmas P.D., Eastell R., Garnero P. et al. The use of biochemical markers of bone turnover in osteoporosis// Osteoporosis Int. 2000 -Vol.11(Suppl.6) P2-17.
11. Eastell R., Bauman M., Hoyle N.R., Wieczorek L., eds. Bone markers:biochemical and clinical perspectives // Roche.Martin Duntz. 2001P.1-252.
12. Fabrega E., Orive A., Garcia-Unzueta M., Amado J.A. et al. 2006.// Osteoprotegerin and receptor activator of nuclear factor kappaB ligand system in the early postoperative period of liver transplantation// Clin Transplant. 2006 Vol. 20(3) P. 383-388.
13. Fahrleitner A., Prenner G., Kniepeiss D., Iberer F. et al. Serum osteoprotegerin levels in patients after liver transplantation and correlation to bone turnover, bone mineral density and fracture status// Wien Klin Wochenschr. 2002 Vol.114(15-16) P717-724.
14. Floreani A., Mega A., Tizian L., Burra P. et al. Bone metabolism and gonad function in male patients undergoing liver transplantation: a two-year longitudinal study.// Osteoporos Int. 2001 Vol.12 P.749-754.
15. Goral V., Simsek M., Mete N. Hepatic osteodystrophy and liver cirrhosis // World J. Gastroenterol. 2010 Vol.16(13) P.1639-1643.
16. Giannini S., Nobile M., Ciuffreda M., Iemmolo R.M. et al. Longterm persistence of low bone density in orthotopic liver transplantation// Osteoporos Int. 2000 Vol. 11P.417-424.
17. Guanabens N., Pares A., Alvarez L., Martinez de Osaba M.J. et al. Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis// J Bone Miner Res. -1998 Vol.13(4) P.731-738.
18. Guanabens N., Enjuanes A., Alvarez L., Peris P. et al. High osteoprotegerin serum levels in primary biliary cirrhosis are associated with disease severity but not wiht the mRNA gene expression in liver tissue// J Bone Miner Metab. 2009 Vol.27(3) P347-354.
19. Guichelaar M.M.J, Malinchoc M, Sibonga J, Clarke BL, Hay J.E. Immunosuppressive and postoperative effects of orthotopic liver transplantation on bone metabolism.// Liver Transpl. 2004 Vol.10 -P. 638-647.
20. Guichelaar M.J., Schmoll J., Malinchoc M., Hay J.E. Fracture and avascular necrosis before and after orthotopic liver transplantation: long-term follow-up and predictive factors// Hepatology. 2007;V.46. P1198-1207].
21. Han Y.P., Zhou L., Wang J. et al. Essential role of matrix metalloproteinases in interleukin 1-induced myofibroblastic activation of hepatic stellate cell collagen//J.Biol.Chem. 2004 -Vol.279 P4820-4828.
22. Irie S., Hayashida N., Shinkawa T., Taira Y. et al. Suitability of tartrate-resistant asid phosphatase type 5b as a screeninig marcer for bone mineral density in community-dwelling elder individuals// Tohoku J.Exp. Med. 2011 Vol. 224 P. 105-110.
23. Jabiry-Zieniewicz Z., Kaminski P., Bobrowska K., Pietrzak B. et al. Menstrual function in female liver transplantat recipients of reproductive age// Transplant Proc. 2009 Vol. 41P. 1735-1739.
24. Kulak C.A., Borba V.Z., Kulak J., Campos D.J., Shane E. Posttransplantation osteoporosis// Arg. Bras. Endocrinol. Metab. 2010 -Vol.52(2) P. 143-149.
25. McCormick R.K. Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility// Alternative Medicine Rewiew. 2007 Vol.12 P 113-145.
26. Misof B.M., Bodingbauer M., Roschger P., Wecerle T. Short-term effects of hige doze zoledronic acid treatment on bone mineralization density distribution after orthopic liver transplantation// Calcif Tissue Int. -2008 Vol.83 P. 167-175.
27. Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone disease after liver transplantation: a long-term prospective study of bone mass changes, hormonal disorders and histomorphometric characteristics.// Osteoporos Int. 2001 Vol.12 P. 484-492.
28. Monegal A., Navasa M., Guanabens N., Peris P. et al. Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A.// Calcif Tissue Int. 2001 Vol. 68 P. 83-86.
29. Seehofer D., Steinmueller T., Graef K-J., Rayes N. et al. Pituitary function test and endocrine ststus in patient with cirrhosis of liver before and after hepatic transplantation// Annals of transplantation. 2002 Vol. 7 P. 32-37.
30. Taki-Eldin A., Zhou L., Xie H.-Y., Zheng S.-S. Liver regeneration after liver transplantation// Eur Surg Res. 2012 Vol. 48 P. 139-153.
31. Theret N., Lehti K., Musso O., Clement B. MMP2 activation by collagen 1 and concanavalin A in cultured human hepatic stellate cells// Hepatology 1999 Vol.30(2) P462-468.
32. Tzimas G.N., Afshar M., Emadali A., Chevet E. et al. Correlation of cell necrosis and tissue calcification with ischemia/reperfusion injury after liver transplantation//Transplantation Proceeding. 2004 Vol. 36 P. 1766-1768.
Review
For citations:
Buzulina V.P., Pronchenko I.A., Ermakova I.P., Shmerko N.P., Andrianova A.A., Kornilov M.N., Yaroshenko E.B., Koliashvili T.K. BIOCHEMICAL MARKERS OF BONE RESORPTION, REGULATION OF OSTEOCLASTOGENESIS AND BONE LOSS FOLLOWING LIVER TRANSPLANTATION. Osteoporosis and Bone Diseases. 2013;16(1):18-23. (In Russ.) https://doi.org/10.14341/osteo2013118-23
Views:
571
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
