The article analyzes the long-term results of surgical treatment of 107 patients with traumatic pathology of the brachioradialis joint, including the use, developed by the authors, models of individual radial head prosthesis. Osteosynthesis in fractures Mason-Johnston type II in 81% of cases showed "excellent" results of surgical treatment, 12.5% - "good" and 6.5% - "satisfactory". The Mason-Johnston type III of long-term results of osteosynthesis in 44% rated as "excellent", 41% - "good", 15% - "poor", and in the case of Mason-Johnston type IV “good" results were observed in 33% of cases, 16% - "satisfactory", 51% - "poor". The osteosynthesis of the capitellium fractures Bryan-Morray I and II shown in, basically, "excellent" and "good" results, while 100% of the osteosynthesis fractures Bryan-Morray III type received "poor" long-term results. Primary arthroplasty of the radial head in a case of multifragmentary fractures type Mason-Johnston III and type IV mainly indicates "excellent" and "good" long-term results. Primary resection of the radial head shows the "bad" long-term results of surgical treatment. Based on these data, an algorithm individualized patient care that improves outcomes in patients with lesions of the above mentioned anatomical region.

Acute hematogenous osteomyelitis with inadequate treatment or no as such can become chronic. The latter involves a problem of not only increasing resistance of microorganisms to antibiotics (ABP), but their stable persistence in the body for a long time. Inability to achieve bactericidal concentrations of antibacterial drugs in the sequester due to lack of blood circulation in pyogenic foci makes inefficient traditional antimicrobial therapy. The purpose of this study - to justify the use of ozonated saline solution in the complex treatment of HGO through experimental research and development of optimal methods of influence on gram (+) and Gram (-) bacteria, fungi of the genus of Candida, Mycobacterium tuberculosis. We have carried out two series of experiments. To approximate the experimental conditions to the in vivo conditions of the surgical wound bacterial culture medium used - mylar fabric is hygroscopic and can largely mitigate the impact of aggressive antiseptic solutions to the CFU, simulating wall abscess (hereinafter referred to as the test object). One of a series of tubes with different concentrations of bacteria were exposed to ozonated saline with different exposures. The presence of colony growth test - bacteria on the test -object on the surface of the culture medium showed that ozone treatment for a given exposure time exposure did not provide a reliable germicidal effect. Lack of growth of colonies test - bacteria on test - and the object in a nutrient medium surface indicates the presence of bactericidal activity. The results of experimental studies have shown the high efficiency of ozonated saline against S. aureus ATCC 25923 with exposure 20 min., Ps. aeruginosa ATCC 27853 at 30 min exposure. In C. albicans strain 401 / 885-653 treatment ozonated saline solution has a bacteriostatic and pronounced inhibitory effect upon exposure of 30 minutes. This allows us to draw a conclusion on the appropriateness and effectiveness of the use of ozonated saline solution in the treatment of chronic hematogenous osteomyelitis of the spine.

In present critical review of systematized materials on the breakthrough achievements of the last decade - the discovery of the effect of protein lactoferrin (LF) on bone formation. It is shownthat LF increases the number of osteoblasts, stimulate their proliferation and differentiation, and prevents their destruction. Action of LF exceeds that of many other previously established bone-forming factors. LF increases the ability of osteoblasts to synthesize and mineralize bone matrix. Apparently, the effect of LF on bone anabolism ensured by the presence of specific receptors on osteoblasts. It was found that LF also inhibits the formation of osteoclasts. Experimental studies have demonstrated that LF prevents the destruction of bone tissue in ovariectomizedanimals and, thus, developing the type of postmenstrual osteoporosis in women. We get the first clinical studies demonstrating an increase in the period of healing of bone injuries while reducing the level of endogenous LF. Since molecular research establishes that the expression of the LF gene is regulated by estrogen, which reduces the development of postmenopausal osteoporosis (PMO) in women, there is a need to further investigate the relationship of these processes, which will help to create a basis for the management of bone formation.

The data from a number of clinical trials investigating a once-yearly infusion of5 mg zoledronic acidshow a marked efficacy of this intervention in the treatment of primary and secondary osteoporosis with a combination of fracture risk reduction and prevention of bone loss at key skeletal sites. Recent research studies demonstrate beneficial features of original and generic zoledronic acid for treatment of patients with osteogenesis imperfecta, primary hyperparathyroidism, Paget’s disease of bone,vertebroplasty and dental implantation.

The development of postsurgical hypoparathyroidism is the most frequent complication of thyroidectomy and radical surgical procedures on the neck. Hypoparathyroidism is a disorder characterized by hypocalcemia, parathyroid hormone (PTH) deficiency, and abnormal bone remodeling. Standard treatment of hypoparathyroidism consists of oral calcium and active forms of vitamin D. However, some patients fail to achieve the normalization of calcium levels with this therapy. We present a clinical case of postsurgical hypoparathyroidism with severe clinical presentation of hypocalcaemia treated with recombinant human PTH 1-34 - teriparatide.

Osteoporosis - is a systemic disease characterized by low bone mass, microarchitectural violation of its structure that leads to an increased risk of fractures. Currently, the method of finding the optimal therapy for osteoporosisis given special attention. In Kazan, September 9, 2016 in the framework of the Russian Congress on Osteoporosis, osteoarthritis and other metabolic diseases of the skeleton was heldAmgen satellite symposium. The event included reports of Russian and foreign experts, dedicated to practical issues of the treatment of osteoporosis and fracture prevention with the particular emphaseson the benefits of using modern antiresorptive agents.